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HAO1

This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids. The transcript detected at high levels in pancreas may represent an alternatively spliced form or the use of a multiple near-consensus upstream polyadenylation site.
Full Name
hydroxyacid oxidase 1, liver
Alternative Names
GO; GOX; Hao; Gox1; Hao-1
Function
Broad substrate specificity (S)-2-hydroxy-acid oxidase that preferentially oxidizes glycolate (PubMed:10777549, PubMed:17669354, PubMed:18215067, PubMed:10978532).

The glyoxylate produced by the oxidation of glycolate can then be utilized by alanine-glyoxylate aminotransferase for the peroxisomal synthesis of glycine; this pathway appears to be an important step for the detoxification of glyoxylate which, if allowed to accumulate, may be metabolized to oxalate with formation of kidney stones (PubMed:10978532, PubMed:17669354).

Can also catalyze the oxidation of glyoxylate, and long chain hydroxyacids such as 2-hydroxyhexadecanoate and 2-hydroxyoctanoate, albeit with much lower catalytic efficiency (PubMed:10777549, PubMed:17669354, PubMed:18215067).

Active in vitro with the artificial electron acceptor 2,6-dichlorophenolindophenol (DCIP), but O2 is believed to be the physiological electron acceptor, leading to the production of H2O2 (PubMed:10777549, PubMed:17669354, PubMed:18215067, PubMed:10978532).

Is not active on L-lactate and 2-hydroxybutanoate (PubMed:10777549).
Biological Process
Fatty acid alpha-oxidation Source: UniProtKB
Glycolate catabolic process Source: UniProtKB
Response to oxidative stress Source: Ensembl
Cellular Location
Peroxisome matrix
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Anti-HAO1 antibodies

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Mouse Anti-HAO1 Recombinant Antibody (CB230) (CBMAB-CS230LY)

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Target: HAO1
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: CB230
Application*: WB
Datasheet SDS

Mouse Anti-HAO1 Recombinant Antibody (3B2) (CBMAB-AP2666LY)

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Target: HAO1
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: 3B2
Application*: IF, IHC, WB
Datasheet SDS

Mouse Anti-HAO1 Recombinant Antibody (CAP878) (CBMAB-AP2665LY)

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Target: HAO1
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: CAP878
Application*: ELISA, WB
Datasheet SDS

Mouse Anti-HAO1 Recombinant Antibody (CB257A) (CBMAB-CA257LY)

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Target: HAO1
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: CB257A
Application*: ELISA, WB
Datasheet SDS

Mouse Anti-HAO1 Recombinant Antibody (CBFYH-0688) (CBMAB-H1578-FY)

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Target: HAO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0688
Application*: F, WB
Datasheet SDS

Rabbit Anti-HAO1 Recombinant Antibody (CBFYH-0687) (CBMAB-H1577-FY)

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Target: HAO1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYH-0687
Application*: E
Datasheet SDS

Mouse Anti-HAO1 Recombinant Antibody (CBFYH-0684) (CBMAB-H1574-FY)

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Target: HAO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0684
Application*: IF, WB
Datasheet SDS

Mouse Anti-HAO1 Recombinant Antibody (CBFYH-0683) (CBMAB-H1573-FY)

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Target: HAO1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-0683
Application*: WB, IH
Datasheet SDS

Mouse Anti-HAO1 Recombinant Antibody (CBFYH-0682) (CBMAB-H1572-FY)

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Target: HAO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Rat, Monkey
Clone: CBFYH-0682
Application*: WB, F
Datasheet SDS

Mouse Anti-HAO1 Recombinant Antibody (CBFYH-0681) (CBMAB-H1571-FY)

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Target: HAO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0681
Application*: WB, IF, F
Datasheet SDS

Mouse Anti-HAO1 (AA 2-370) Recombinant Antibody (CBFYH-0680) (CBMAB-H1570-FY)

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Target: HAO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBFYH-0680
Application*: WB
Datasheet SDS

Mouse Anti-HAO1 Recombinant Antibody (CBFYH-2850) (CBMAB-H1569-FY)

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Target: HAO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2850
Application*: P
Datasheet SDS

Mouse Anti-HAO1 Recombinant Antibody (CBT44) (V2LY-0625-LY3844)

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Target: HAO1
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: CBT44
Application*: WB, P, IF, IC
Datasheet SDS

Mouse Anti-HAO1 Recombinant Antibody (EC165) (V2LY-0624-LY165)

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Target: HAO1
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: EC165
Application*: WB, P, IF
Datasheet SDS

Mouse Anti-HAO1 Recombinant Antibody (EG1475) (CBMAB-EN1762-LY)

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Target: HAO1
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: EG1475
Application*: WB, IF, IHC-p
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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