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HMOX1

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008]
Full Name
Heme Oxygenase 1
Function
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.
Biological Process
Angiogenesis Source: BHF-UCL
Cell death Source: BHF-UCL
Cellular iron ion homeostasis Source: CACAO
Cellular response to arsenic-containing substance Source: Ensembl
Cellular response to cadmium ion Source: Ensembl
Cellular response to cisplatin Source: Ensembl
Cellular response to heat Source: UniProtKB
Cellular response to hypoxia Source: UniProtKB
Cellular response to nutrient Source: Ensembl
Endothelial cell proliferation Source: BHF-UCL
Erythrocyte homeostasis Source: BHF-UCL
Excretion Source: BHF-UCL
Heme catabolic process Source: BHF-UCL
Heme oxidation Source: BHF-UCL
Intracellular signal transduction Source: BHF-UCL
Intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
Iron ion homeostasis Source: BHF-UCL
Liver regeneration Source: Ensembl
Low-density lipoprotein particle clearance Source: BHF-UCL
Negative regulation of DNA binding Source: Ensembl
Negative regulation of DNA-binding transcription factor activity Source: Ensembl
Negative regulation of epithelial cell apoptotic process Source: Ensembl
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: BHF-UCL
Negative regulation of leukocyte migration Source: BHF-UCL
Negative regulation of macroautophagy Source: Ensembl
Negative regulation of mast cell cytokine production Source: Ensembl
Negative regulation of mast cell degranulation Source: Ensembl
Negative regulation of muscle cell apoptotic process Source: Ensembl
Negative regulation of neuron apoptotic process Source: Ensembl
Negative regulation of smooth muscle cell proliferation Source: UniProtKB
Negative regulation of vascular associated smooth muscle cell proliferation Source: Ensembl
Positive regulation of angiogenesis Source: BHF-UCL
Positive regulation of apoptotic process Source: Ensembl
Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: BHF-UCL
Positive regulation of cell migration involved in sprouting angiogenesis Source: BHF-UCL
Positive regulation of chemokine production Source: BHF-UCL
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Positive regulation of macroautophagy Source: Ensembl
Positive regulation of smooth muscle cell proliferation Source: UniProtKB
Regulation of angiogenesis Source: BHF-UCL
Regulation of blood pressure Source: Ensembl
Regulation of DNA-binding transcription factor activity Source: BHF-UCL
Regulation of transcription from RNA polymerase II promoter in response to iron Source: Ensembl
Regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: BHF-UCL
Response to estrogen Source: Ensembl
Response to hydrogen peroxide Source: BHF-UCL
Response to nicotine Source: BHF-UCL
Response to oxidative stress Source: BHF-UCL
Response to xenobiotic stimulus Source: Ensembl
Small GTPase mediated signal transduction Source: Ensembl
Smooth muscle hyperplasia Source: BHF-UCL
Wound healing involved in inflammatory response Source: BHF-UCL
Cellular Location
Microsome; Endoplasmic reticulum membrane
Involvement in disease
Heme oxygenase 1 deficiency (HMOX1D):
A disease characterized by impaired stress hematopoiesis, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. Clinical features include persistent hemolytic anemia, asplenia, nephritis, generalized erythematous rash, growth retardation and hepatomegaly.

Anti-HMOX1 antibodies

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Target: HMOX1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBFYH-1571
Application*: E, IH, WB
Target: HMOX1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-1568
Application*: E, WB
Target: HMOX1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Guinea pig
Clone: EP1391Y
Application*: P, IP, F, WB
Target: HMOX1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Cattle, Dog, Monkey
Clone: HO-1-1
Application*: E, F, IC, IF, C, P, IP, WB
Target: HMOX1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rat, Mouse, Guinea pig, Hamster, Dog, Human, Monkey
Clone: HO-1-2
Application*: F
Target: HMOX1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat, Rabbit, Pig, Monkey, Hamster, Guinea pig, Dog
Clone: CBFYH-2922
Application*: WB
Target: HMOX1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Cattle, Dog, Guinea pig, Hamster, Monkey, Pig, Rabbit
Clone: CBFYH-3172
Application*: WB, IH, IF, IP, E
Target: HMOX1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-3173
Application*: WB, IF
Target: HMOX1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 6B8-2F2
Application*: WB, IF
Target: HMOX1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: D60G11
Application*: WB, IP
Target: HMOX1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Human
Clone: GTS-1
Application*: WB, E, P, C, F, I
Target: HMOX1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Dog, Mouse, Rat
Clone: CBFYH-2923
Application*: F, IC, P, WB
Target: HMOX1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYH-1561
Application*: E, WB
Target: HMOX1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBFYH-1562
Application*: WB, P, IP, F
Target: HMOX1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBFYH-1563
Application*: WB
Target: HMOX1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-1564
Application*: E, IC, P, IP, WB
Target: HMOX1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYH-1565
Application*: WB, IC, P, C, E, IP, IF, F
Target: HMOX1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-1567
Application*: WB, F, E, IF
Target: HMOX1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 5C6
Application*: WB, E
Target: HMOX1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: E3F4S
Application*: WB, IP
Target: HMOX1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: E9H3A
Application*: WB, IP, IF, IF (IC)
Target: HMOX1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Cattle, Dog, Guinea pig, Hamster, Human, Monkey, Mouse, Pig, Rabbit, Rat
Clone: A247
Application*: ICC/IF, ELISA, IHC, IP, WB
Target: HMOX1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Cattle, Dog, Guinea pig, Hamster, Human, Monkey, Mouse, Pig, Rabbit, Rat
Clone: A248
Application*: ICC/IF, ELISA, IHC, IP, WB
Target: HMOX1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Cattle, Dog, Guinea pig, Hamster, Human, Monkey, Mouse, Pig, Rabbit, Rat
Clone: A249
Application*: ICC/IF, ELISA, IHC, IP, WB
Target: HMOX1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: A250
Application*: ICC/IF, WB
Target: HMOX1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A251
Application*: ICC, IHC, IP, WB
Target: HMOX1
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: A252
Application*: ICC, IHC, IP, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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