HPV16-E7

Full Name

HPV16-E7

Function

Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).

Biological Process

Modulation by virus of host G1/S transition checkpoint Source: UniProtKB-UniRule
Modulation by virus of host transcription Source: UniProtKB
Positive regulation by symbiont of host transcription Source: UniProtKB
Positive regulation of actin filament polymerization Source: UniProtKB
Suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Suppression by virus of host JAK-STAT cascade via inhibition of host IRF9 activity Source: UniProtKB
Suppression by virus of host type I interferon-mediated signaling pathway Source: UniProtKB-UniRule
Transcription, DNA-templated Source: UniProtKB-UniRule

Cellular Location

Host cytoplasm; Host nucleus. Predominantly found in the host nucleus.

PTM

Highly phosphorylated.