HTRA3

HTRA3 (HtrA Serine Peptidase 3) is a Protein Coding gene. Diseases associated with HTRA3 include Ovary Serous Adenocarcinoma and Ovarian Cystadenocarcinoma. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and endopeptidase activity. An important paralog of this gene is HTRA1.

Full Name

HtrA serine peptidase 3

Function

Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity).

May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (PubMed:21321049, PubMed:22229724).

Biological Process

Negative regulation of BMP signaling pathway Source: UniProtKB
Negative regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
Proteolysis Source: UniProtKB

Cellular Location

Secreted. Secretion increased during decidualization of endometrial stromal cells.