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Mouse Anti-HTRA3 (AA 344-453) Recombinant Antibody (CBFYH-2527) (CBMAB-H3541-FY)

This product is mouse antibody that recognizes HTRA3. The antibody CBFYH-2527 can be used for immunoassay techniques such as: ELISA, WB.
See all HTRA3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-2527
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: FQDKQIKDWK KRFIGIRMRT ITPSLVDELK ASNPDFPEVS SGIYVQEVAP NSPSQRGGIQ DGDIIVKVNG RPLVDSSELQ EAVLTESPLL LEVRRGNDDL LFSIAPEVVM
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 344-453

Target

Full Name
HtrA serine peptidase 3
Introduction
HTRA3 (HtrA Serine Peptidase 3) is a Protein Coding gene. Diseases associated with HTRA3 include Ovary Serous Adenocarcinoma and Ovarian Cystadenocarcinoma. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and endopeptidase activity. An important paralog of this gene is HTRA1.
Entrez Gene ID
94031
UniProt ID
P83110
Alternative Names
HtrA Serine Peptidase 3; Pregnancy-Related Serine Protease; High-Temperature Requirement Factor A3; Prsp; Probable Serine Protease HTRA3; Serine Protease HTRA3
Function
Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity).

May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (PubMed:21321049, PubMed:22229724).
Biological Process
Negative regulation of BMP signaling pathway Source: UniProtKB
Negative regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
Proteolysis Source: UniProtKB
Cellular Location
Secreted. Secretion increased during decidualization of endometrial stromal cells.

Xu, Q., Wang, J., Wang, J., Zhu, Y., Chen, B., Guo, R., ... & Liu, F. (2023). A pan-cancer analysis to provide insight into the immunological role and prognostic value of HTRA3. Critical Reviews™ in Eukaryotic Gene Expression, 33.

Ko, T., Nomura, S., Yamada, S., Fujita, K., Fujita, T., Satoh, M., ... & Komuro, I. (2022). Cardiac fibroblasts regulate the development of heart failure via Htra3-TGF-β-IGFBP7 axis. Nature communications, 13(1), 3275.

Guo, Y., Ma, S., Xu, M., Wei, Y., Zhang, X., Huang, Y., ... & Deng, X. (2021). HtrA3‐Mediated Endothelial Cell–Extracellular Matrix Crosstalk Regulates Tip Cell Specification. Advanced Functional Materials, 31(30), 2100633.

Acharya, S., Dutta, S., & Bose, K. (2020). A distinct concerted mechanism of structural dynamism defines activity of human serine protease HtrA3. Biochemical Journal, 477(2), 407-429.

Ji, C., Sun, L. S., Xing, F., Niu, N., Gao, H. L., Dai, J. W., ... & Jiang, B. C. (2020). HTRA3 is a prognostic biomarker and associated with immune infiltrates in gastric cancer. Frontiers in oncology, 10, 603480.

Wenta, T., Rychlowski, M., Jurewicz, E., Jarzab, M., Zurawa‐Janicka, D., Filipek, A., & Lipinska, B. (2019). The HtrA3 protease promotes drug‐induced death of lung cancer cells by cleavage of the X‐linked inhibitor of apoptosis protein (XIAP). The FEBS Journal, 286(22), 4579-4596.

Zhao, J., Feng, M., Liu, D., Liu, H., Shi, M., Zhang, J., & Qu, J. (2019). Antagonism between HTRA3 and TGFβ1 Contributes to Metastasis in Non–Small Cell Lung Cancer. Cancer Research, 79(11), 2853-2864.

Wenta, T., Zurawa-Janicka, D., Rychlowski, M., Jarzab, M., Glaza, P., Lipinska, A., ... & Lipinska, B. (2018). HtrA3 is a cellular partner of cytoskeleton proteins and TCP1α chaperonin. Journal of proteomics, 177, 88-111.

Lv, Q., Yang, B., Ning, C., Xie, B., Nie, G., Chen, X., & Chen, Q. (2018). Hypoxia is involved in the reduction of HtrA3 in patients with endometrial hyperplasia and cancer. Biochemical and biophysical research communications, 503(4), 2918-2923.

Wang, Y., Li, Y., Hyett, J., da Silva Costa, F., & Nie, G. (2018). HtrA3 isoform–specific ELISAs for early detection of preeclampsia. SLAS DISCOVERY: Advancing Life Sciences R&D, 23(10), 1092-1099.

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For research use only. Not intended for any clinical use.

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