KLF5

This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

Full Name

KLF5

Function

Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.

Biological Process

AngiogenesisIEA:Ensembl
Cell-cell signaling via exosomeManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular response to leukemia inhibitory factorIEA:Ensembl
Intestinal epithelial cell developmentIEA:Ensembl
Microvillus assemblyIEA:Ensembl
Myotube differentiation involved in skeletal muscle regenerationIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Positive regulation of fat cell differentiationIEA:Ensembl
Positive regulation of pri-miRNA transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Positive regulation of transcription by transcription factor localizationIEA:Ensembl
Regulation of microvillus assemblyIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Satellite cell activation involved in skeletal muscle regenerationIEA:Ensembl
Skeletal muscle satellite cell differentiationIEA:Ensembl

Cellular Location

Nucleus

PTM

Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.