LARS2

This gene encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. [provided by RefSeq]
Full Name
leucyl-tRNA synthetase 2, mitochondrial
Function
Catalyzes the attachment of leucine to its cognate tRNA.
Biological Process
Leucyl-tRNA aminoacylationManual Assertion Based On ExperimentIDA:HGNC
Mitochondrial translationManual Assertion Based On ExperimentIBA:GO_Central
tRNA aminoacylation for protein translationTAS:Reactome
Cellular Location
Mitochondrion matrix
Involvement in disease
Perrault syndrome 4 (PRLTS4):
An autosomal recessive, sex-influenced disorder characterized by sensorineural deafness in both males and females, and ovarian dysgenesis in females. Affected females have primary amenorrhea, streak gonads, and infertility, whereas affected males show normal pubertal development and are fertile.
Hydrops, lactic acidosis, and sideroblastic anemia (HLASA):
A lethal, multisystem metabolic disorder characterized by severe lactic acidosis, hydrops, and sideroblastic anemia. Additional features include impaired cardiac function, disordered coagulation, pulmonary hypertension, and progressive renal disease.
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Anti-LARS2 antibodies

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Mouse Anti-LARS2 Recombinant Antibody (CBYJL-1198) (CBMAB-L0704-YJ)

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Target: LARS2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJL-1198
Application*: E
Datasheet SDS

Mouse Anti-LARS2 Recombinant Antibody (CBYJL-1195) (CBMAB-L0701-YJ)

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Target: LARS2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1195
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-LARS2 Recombinant Antibody (31C2a) (CBMAB-L0699-YJ)

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Target: LARS2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 31C2a
Application*: DB, IC
Datasheet SDS
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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