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LAT2

LAT2 (Linker For Activation Of T Cells Family Member 2) is a Protein Coding gene. This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. Diseases associated with LAT2 include Williams-Beuren Syndrome. Among its related pathways are Immune response Fc epsilon RI pathway and B Cell Receptor Signaling Pathway (sino).

Full Name

linker for activation of T cells family, member 2

Function

Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.

Biological Process

Adaptive immune responseIEA:UniProtKB-KW
B cell activationManual Assertion Based On ExperimentIDA:HGNC-UCL
B cell receptor signaling pathwayManual Assertion Based On ExperimentIDA:HGNC-UCL
Calcium-mediated signalingManual Assertion Based On ExperimentIGI:HGNC-UCL
Intracellular signal transductionManual Assertion Based On ExperimentIGI:HGNC-UCL
Mast cell degranulationIEA:UniProtKB-KW

Cellular Location

Cell membrane
Present in lipid rafts.

Involvement in disease

LAT2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of LAT2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.

Topology

Extracellular: 1-5
Helical: 6-26
Cytoplasmic: 27-243

PTM

Phosphorylated on tyrosines following cross-linking of BCR in B-cells, FCGR1 in myeloid cells, or FCER1 in mast cells; which induces the recruitment of GRB2.
May be polyubiquitinated.

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Anti-LAT2 antibodies

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Mouse Anti-LAT2 Recombinant Antibody (CBWJN-1119) (CBMAB-N0918-WJ)

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Target: LAT2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBWJN-1119

Application*: WB, P, IP

Mouse Anti-LAT2 Recombinant Antibody (F-9) (CBMAB-N0915-WJ)

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Target: LAT2

Host: Mouse

Specificity: Human

Clone: F-9

Application*: WB, IP, IF, E

Rabbit Anti-LAT2 Recombinant Antibody (D7I2B) (CBMAB-N0914-WJ)

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Target: LAT2

Host: Rabbit

Specificity: Human

Clone: D7I2B

Application*: WB, IF, F

Mouse Anti-LAT2 Recombinant Antibody (CBWJN-0468) (CBMAB-N0913-WJ)

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Target: LAT2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: CBWJN-0468

Application*: F, IC, IH, IP, WB

Rabbit Anti-LAT2 Recombinant Antibody (CBWJN-0185) (CBMAB-N0912-WJ)

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Target: LAT2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBWJN-0185

Application*: F, IF, WB

Mouse Anti-LAT2 Recombinant Antibody (CBWJN-0918) (CBMAB-N0065-WJ)

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Target: LAT2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJN-0918

Application*: WB, IP, F

Mouse Anti-LAT2 Recombinant Antibody (CBWJN-0917) (CBMAB-N0062-WJ)

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Target: LAT2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBWJN-0917

Application*: WB, F, MC

Mouse Anti-LAT2 Recombinant Antibody (CBYJL-1211) (CBMAB-L0726-YJ)

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Target: LAT2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYJL-1211

Application*: P, IP, WB

Mouse Anti-LAT2 Recombinant Antibody (CBYJL-1210) (CBMAB-L0725-YJ)

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Target: LAT2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJL-1210

Application*: IC, P, IP, WB

Mouse Anti-LAT2 Recombinant Antibody (NAP-07) (CBMAB-L0724-YJ)

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Target: LAT2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: NAP-07

Application*: F

Mouse Anti-LAT2 Recombinant Antibody (NAP-03) (CBMAB-L0723-YJ)

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Target: LAT2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: NAP-03

Application*: P, CT, IP, WB

Mouse Anti-LAT2 Recombinant Antibody (CBYJL-1209) (CBMAB-L0722-YJ)

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Target: LAT2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJL-1209

Application*: P, IP, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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