LAT2

LAT2 (Linker For Activation Of T Cells Family Member 2) is a Protein Coding gene. This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. Diseases associated with LAT2 include Williams-Beuren Syndrome. Among its related pathways are Immune response Fc epsilon RI pathway and B Cell Receptor Signaling Pathway (sino).
Full Name
linker for activation of T cells family, member 2
Function
Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
Biological Process
Adaptive immune responseIEA:UniProtKB-KW
B cell activationManual Assertion Based On ExperimentIDA:HGNC-UCL
B cell receptor signaling pathwayManual Assertion Based On ExperimentIDA:HGNC-UCL
Calcium-mediated signalingManual Assertion Based On ExperimentIGI:HGNC-UCL
Intracellular signal transductionManual Assertion Based On ExperimentIGI:HGNC-UCL
Mast cell degranulationIEA:UniProtKB-KW
Cellular Location
Cell membrane
Present in lipid rafts.
Involvement in disease
LAT2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of LAT2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
Topology
Extracellular: 1-5
Helical: 6-26
Cytoplasmic: 27-243
PTM
Phosphorylated on tyrosines following cross-linking of BCR in B-cells, FCGR1 in myeloid cells, or FCER1 in mast cells; which induces the recruitment of GRB2.
May be polyubiquitinated.
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Anti-LAT2 antibodies

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Mouse Anti-LAT2 Recombinant Antibody (CBWJN-1119) (CBMAB-N0918-WJ)

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Target: LAT2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJN-1119
Application*: WB, P, IP
Datasheet SDS

Mouse Anti-LAT2 Recombinant Antibody (F-9) (CBMAB-N0915-WJ)

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Target: LAT2
Host: Mouse
Specificity: Human
Clone: F-9
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-LAT2 Recombinant Antibody (D7I2B) (CBMAB-N0914-WJ)

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Target: LAT2
Host: Rabbit
Specificity: Human
Clone: D7I2B
Application*: WB, IF, F
Datasheet SDS

Mouse Anti-LAT2 Recombinant Antibody (CBWJN-0468) (CBMAB-N0913-WJ)

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Target: LAT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBWJN-0468
Application*: F, IC, IH, IP, WB
Datasheet SDS

Rabbit Anti-LAT2 Recombinant Antibody (CBWJN-0185) (CBMAB-N0912-WJ)

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Target: LAT2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJN-0185
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-LAT2 Recombinant Antibody (CBWJN-0918) (CBMAB-N0065-WJ)

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Target: LAT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0918
Application*: WB, IP, F
Datasheet SDS

Mouse Anti-LAT2 Recombinant Antibody (CBWJN-0917) (CBMAB-N0062-WJ)

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Target: LAT2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJN-0917
Application*: WB, F, MC
Datasheet SDS

Mouse Anti-LAT2 Recombinant Antibody (CBYJL-1211) (CBMAB-L0726-YJ)

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Target: LAT2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-1211
Application*: P, IP, WB
Datasheet SDS

Mouse Anti-LAT2 Recombinant Antibody (CBYJL-1210) (CBMAB-L0725-YJ)

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Target: LAT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1210
Application*: IC, P, IP, WB
Datasheet SDS

Mouse Anti-LAT2 Recombinant Antibody (NAP-07) (CBMAB-L0724-YJ)

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Target: LAT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: NAP-07
Application*: F
Datasheet SDS

Mouse Anti-LAT2 Recombinant Antibody (NAP-03) (CBMAB-L0723-YJ)

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Target: LAT2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: NAP-03
Application*: P, CT, IP, WB
Datasheet SDS

Mouse Anti-LAT2 Recombinant Antibody (CBYJL-1209) (CBMAB-L0722-YJ)

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Target: LAT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1209
Application*: P, IP, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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