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Mouse Anti-LAT2 Recombinant Antibody (CBYJL-1209) (CBMAB-L0722-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Linker For Activation Of T Cells Family Member 2 (LAT2). The antibody can be used for immunoassay techniques, such as IHC-P, IP, WB.
See all LAT2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-1209
Antibody Isotype
IgG1
Application
IHC-P, IP, WB

Basic Information

Immunogen
Peptide corresponding to aa 196-212 of human NTAL coupled to KLH.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 196-212

Target

Full Name
linker for activation of T cells family, member 2
Introduction
LAT2 is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. Diseases associated with LAT2 include Williams-Beuren Syndrome. Among its related pathways are Immune response Fc epsilon RI pathway and B Cell Receptor Signaling Pathway (sino). It is involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. LAT2 may also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
Entrez Gene ID
7462
UniProt ID
Q9GZY6
Alternative Names
HSPC046; LAB; NTAL; WBSCR15; WBSCR5; WSCR5
Function
Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
Biological Process
Adaptive immune responseIEA:UniProtKB-KW
B cell activationManual Assertion Based On ExperimentIDA:HGNC-UCL
B cell receptor signaling pathwayManual Assertion Based On ExperimentIDA:HGNC-UCL
Calcium-mediated signalingManual Assertion Based On ExperimentIGI:HGNC-UCL
Intracellular signal transductionManual Assertion Based On ExperimentIGI:HGNC-UCL
Mast cell degranulationIEA:UniProtKB-KW
Cellular Location
Cell membrane
Present in lipid rafts.
Involvement in disease
LAT2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of LAT2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
Topology
Extracellular: 1-5
Helical: 6-26
Cytoplasmic: 27-243
PTM
Phosphorylated on tyrosines following cross-linking of BCR in B-cells, FCGR1 in myeloid cells, or FCER1 in mast cells; which induces the recruitment of GRB2.
May be polyubiquitinated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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