MARCO

The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq, Jul 2008]
Full Name
Macrophage Receptor With Collagenous Structure
Function
Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria (PubMed:9468508).

Also plays a role in binding of unopsonized particles by alveolar macrophages (By similarity).

Binds to the secretoglobin SCGB3A2 (PubMed:12847263).
Biological Process
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: ARUK-UCL
Amyloid-beta clearance Source: ARUK-UCL
Apoptotic cell clearance Source: Ensembl
Cell surface receptor signaling pathway Source: ProtInc
Endocytosis Source: GO_Central
Innate immune response Source: UniProtKB-KW
Phagocytosis, engulfment Source: ARUK-UCL
Positive regulation of ERK1 and ERK2 cascade Source: ARUK-UCL
Positive regulation of protein phosphorylation Source: ARUK-UCL
Receptor-mediated endocytosis Source: ARUK-UCL
Cellular Location
Plasma membrane
Cell membrane
Topology
Cytoplasmic: 1-43
Helical: 44-64
Extracellular: 65-520
PTM
N-glycosylated.
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Anti-MARCO antibodies

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Recombinant Mouse Anti-MARCO Antibody (CBHb259) (CBMAB-Hb714-LY)

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Target: MARCO
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human, Cattle
Clone: CBHb259
Application*: FC, IHC-F, FuncS, IF, IP, WB
Datasheet SDS

Rat Anti-MARCO (C-terminus) Recombinant Antibody (CBFYM-1716) (CBMAB-M1883-FY)

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Target: MARCO
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBFYM-1716
Application*: F, IF, C, WB
Datasheet SDS

Mouse Anti-MARCO (AA 420-431) Recombinant Antibody (CBFYM-1715) (CBMAB-M1882-FY)

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Target: MARCO
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human, Cattle
Clone: CBFYM-1715
Application*: IF, C, IP, WB, FN
Datasheet SDS

Human Anti-MARCO Recombinant Antibody (CBFYM-1714) (CBMAB-M1881-FY)

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Target: MARCO
Host: Human
Antibody Isotype: IgG3
Specificity: Cattle
Clone: CBFYM-1714
Application*: F, IF, IP, WB
Datasheet SDS

Rat Anti-MARCO Recombinant Antibody (CBFYM-0581) (CBMAB-M0710-FY)

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Target: MARCO
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBFYM-0581
Application*: IH, WB
Datasheet SDS

Mouse Anti-MARCO Recombinant Antibody (CBFYM-0389) (CBMAB-M0488-FY)

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Target: MARCO
Host: Mouse
Antibody Isotype: IgM
Specificity: Hamster
Clone: CBFYM-0389
Application*: F, IH, IP, C
Datasheet SDS

Rat Anti-MARCO Recombinant Antibody (CBFYM-0273) (CBMAB-M0338-FY)

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Target: MARCO
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBFYM-0273
Application*: F, IP
Datasheet SDS

Rat Anti-MARCO (AA 70-518) Recombinant Antibody (CBFYM-0172) (CBMAB-M0197-FY)

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Target: MARCO
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBFYM-0172
Application*: F
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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