Recombinant Mouse Anti-MARCO Antibody (CBHb259) (CBMAB-Hb714-LY)

Name: Recombinant Mouse Anti-MARCO Antibody (CBHb259)
SKU: CBMAB-Hb714-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBHb259

Application

FC, IHC-F, FuncS, IF, IP, WB

Immunogen

Human alveolar macrophages (recognizes domain V between residues 420 and 431)

Specificity

Human, Cattle

Antibody Isotype

IgG3

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

0.1% BSA

Concentration

0.1 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Macrophage Receptor With Collagenous Structure

Introduction

The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq, Jul 2008]

Entrez Gene ID

Human	8685
Cattle	505632

UniProt ID

Human	Q9UEW3
Cattle	F1N7K7

Alternative Names

Macrophage Receptor With Collagenous Structure; Scavenger Receptor Class A, Member 2; SCARA2; Scavenger Receptor Class A Member 2; Macrophage Receptor MARCO; SR-A6;

Function

Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria (PubMed:9468508).

Also plays a role in binding of unopsonized particles by alveolar macrophages (By similarity).

Binds to the secretoglobin SCGB3A2 (PubMed:12847263).

Biological Process

Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: ARUK-UCL
Amyloid-beta clearance Source: ARUK-UCL
Apoptotic cell clearance Source: Ensembl
Cell surface receptor signaling pathway Source: ProtInc
Endocytosis Source: GO_Central
Innate immune response Source: UniProtKB-KW
Phagocytosis, engulfment Source: ARUK-UCL
Positive regulation of ERK1 and ERK2 cascade Source: ARUK-UCL
Positive regulation of protein phosphorylation Source: ARUK-UCL
Receptor-mediated endocytosis Source: ARUK-UCL

Cellular Location

Plasma membrane
Cell membrane

Topology

Cytoplasmic: 1-43
Helical: 44-64
Extracellular: 65-520

PTM

N-glycosylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Rat Anti-MARCO Recombinant Antibody (CBFYM-0581) (CAT#: CBMAB-M0710-FY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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