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Rat Anti-MARCO (AA 70-518) Recombinant Antibody (CBFYM-0172) (CBMAB-M0197-FY)

This product is rat antibody that recognizes MARCO. The antibody CBFYM-0172 can be used for immunoassay techniques such as: FC.
See all MARCO antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBFYM-0172
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse MARCO, Gln70-Ser518
Specificity
Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 70-518

Target

Full Name
Macrophage Receptor With Collagenous Structure
Introduction
The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains.
Entrez Gene ID
17167
UniProt ID
Q60754
Alternative Names
Macrophage Receptor With Collagenous Structure; Scavenger Receptor Class A, Member 2; SCARA2; Scavenger Receptor Class A Member 2; Macrophage Receptor MARCO; SR-A6
Function
Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria (PubMed:9468508).

Also plays a role in binding of unopsonized particles by alveolar macrophages (By similarity).

Binds to the secretoglobin SCGB3A2 (PubMed:12847263).
Biological Process
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: ARUK-UCL
Amyloid-beta clearance Source: ARUK-UCL
Apoptotic cell clearance Source: Ensembl
Cell surface receptor signaling pathway Source: ProtInc
Endocytosis Source: GO_Central
Innate immune response Source: UniProtKB-KW
Phagocytosis, engulfment Source: ARUK-UCL
Positive regulation of ERK1 and ERK2 cascade Source: ARUK-UCL
Positive regulation of protein phosphorylation Source: ARUK-UCL
Receptor-mediated endocytosis Source: ARUK-UCL
Cellular Location
Plasma membrane
Cell membrane
Topology
Cytoplasmic: 1-43
Helical: 44-64
Extracellular: 65-520
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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