MEPE

This gene encodes a secreted calcium-binding phosphoprotein that belongs to the small integrin-binding ligand, N-linked glycoprotein (SIBLING) family of proteins. Members of this family are components of the extracellular matrix of bone and dentin and regulate bone mineralization. Deficiency of a similar protein in mouse results in increased bone mass. Mice lacking this gene are resistant to aging-related trabecular bone loss. Alternative splicing results in multiple transcript variants.

Full Name

MATRIX EXTRACELLULAR PHOSPHOGLYCOPROTEIN

Function

Promotes renal phosphate excretion and inhibits intestinal phosphate absorption (PubMed:14962809, PubMed:19005008).

Promotes bone mineralization by osteoblasts and cartilage mineralization by chondrocytes (PubMed:18162525, PubMed:19998030, PubMed:22766095).

Regulates the mineralization of the extracellular matrix of the craniofacial complex, such as teeth, bone and cartilage (By similarity).

Promotes dental pulp stem cell proliferation and differentiation (PubMed:22341070).

Biological Process

Biomineral tissue development Source: GO_Central
Skeletal system development Source: ProtInc

Cellular Location

Extracellular matrix

PTM

Phosphorylated on serine residues in the ASARM motif (in vitro) by FAM20C; the phosphorylation is important for the inhibition of bone mineralization (PubMed:19998030, PubMed:22582013).
Cleaved by CTSB/cathepsin B; the cleavage is blocked by metalloprotease PHEX.