MKNK1

This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012]
Full Name
MAP Kinase Interacting Serine/Threonine Kinase 1
Function
May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.
Biological Process
Intracellular signal transduction Source: UniProtKB
Peptidyl-serine phosphorylation Source: BHF-UCL
Protein autophosphorylation Source: GO_Central
Protein phosphorylation Source: UniProtKB
Regulation of translation Source: UniProtKB-KW
Cellular Location
Isoform 2:
Cytoplasm
Isoform 3:
Cytoplasm
Nucleus
PTM
Dual phosphorylation of Thr-250 and Thr-255 activates the kinase. Phosphorylation of Thr-385 activates the kinase. MAPK3/ERK1 is one of the kinases which activate MKNK1/MNK1. Phosphorylation by PAK2 leads to a reduced phosphorylation of EIF4G1.
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Anti-MKNK1 antibodies

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Mouse Anti-MKNK1 Recombinant Antibody (3G6) (CBMAB-A5500-LY)

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Target: MKNK1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3G6
Application*: WB, E
Datasheet SDS

Mouse Anti-MKNK1 Recombinant Antibody (3C9) (CBMAB-A5499-LY)

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Target: MKNK1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: 3C9
Application*: WB, E
Datasheet SDS

Mouse Anti-MKNK1 Recombinant Antibody (2F12) (CBMAB-A5497-LY)

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Target: MKNK1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2F12
Application*: WB, E
Datasheet SDS

Mouse Anti-MKNK1 Recombinant Antibody (5E2) (CBMAB-A5493-LY)

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Target: MKNK1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 5E2
Application*: WB, E
Datasheet SDS

Mouse Anti-MKNK1 Recombinant Antibody (3E1) (CBMAB-A5492-LY)

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Target: MKNK1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3E1
Application*: WB, E
Datasheet SDS

Mouse Anti-MKNK1 (AA 1-362) Recombinant Antibody (CBFYM-2263) (CBMAB-M2448-FY)

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Target: MKNK1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYM-2263
Application*: E, P, WB
Datasheet SDS

Rabbit Anti-MKNK1 Recombinant Antibody (CBFYM-2262) (CBMAB-M2447-FY)

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Target: MKNK1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBFYM-2262
Application*: WB
Datasheet SDS

Mouse Anti-MKNK1 (AA 1-466) Recombinant Antibody (CBFYM-2261) (CBMAB-M2446-FY)

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Target: MKNK1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-2261
Application*: E, IF, IH, WB
Datasheet SDS

MKNK1 Matched Antibody Pair (737) (APMAB-737LY)

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Target: MKNK1
Specificity: Human
Datasheet SDS

Rabbit Anti-MKNK1 Recombinant Antibody (C4C1) (CBMAB-CP1569-LY)

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Target: MKNK1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: C4C1
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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