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Rabbit Anti-MKNK1 Recombinant Antibody (CBFYM-2262) (CBMAB-M2447-FY)

This product is rabbit antibody that recognizes MKNK1. The antibody CBFYM-2262 can be used for immunoassay techniques such as: WB.
See all MKNK1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
CBFYM-2262
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Synthetic peptide corresponding to the sequence of human Mnk1
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
HEPES, pH 7.5, 0.15 M NaCl, 0.01% BSA, 50% glycerol
Preservative
0.02% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MAP Kinase Interacting Serine/Threonine Kinase 1
Introduction
This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene.
Entrez Gene ID
Human8569
Mouse17346
UniProt ID
HumanQ9BUB5
MouseO08605
Alternative Names
MAP Kinase Interacting Serine/Threonine Kinase 1; MAP Kinase Signal-Integrating Kinase 1; MAPK Signal-Integrating Kinase 1; EC 2.7.11.1; MNK1; MAP Kinase-Interacting Serine/Threonine-Protein Kinase 1; EC 2.7.11
Function
May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.
Biological Process
Intracellular signal transduction Source: UniProtKB
Peptidyl-serine phosphorylation Source: BHF-UCL
Protein autophosphorylation Source: GO_Central
Protein phosphorylation Source: UniProtKB
Regulation of translation Source: UniProtKB-KW
Cellular Location
Isoform 2:
Cytoplasm
Isoform 3:
Cytoplasm
Nucleus
PTM
Dual phosphorylation of Thr-250 and Thr-255 activates the kinase. Phosphorylation of Thr-385 activates the kinase. MAPK3/ERK1 is one of the kinases which activate MKNK1/MNK1. Phosphorylation by PAK2 leads to a reduced phosphorylation of EIF4G1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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