MLST8

MLST8 (MTOR Associated Protein, LST8 Homolog) is a Protein Coding gene. Diseases associated with MLST8 include Benign Familial Neonatal Epilepsy and Childhood Absence Epilepsy. Among its related pathways are Constitutive Signaling by AKT1 E17K in Cancer and RET signaling.

MTOR Associated Protein, LST8 Homolog

Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'.

Cellular response to DNA damage stimulus Source: ComplexPortal
Cellular response to hypoxia Source: ComplexPortal
Cellular response to nutrient levels Source: ComplexPortal
Cellular response to osmotic stress Source: ComplexPortal
Cytoskeleton organization Source: ComplexPortal
Negative regulation of apoptotic process Source: ComplexPortal
Negative regulation of autophagy Source: ComplexPortal
Phosphorylation Source: ComplexPortal
Positive regulation of actin filament polymerization Source: Ensembl
Positive regulation of cell growth Source: ComplexPortal
Positive regulation of glycolytic process Source: ComplexPortal
Positive regulation of lipid biosynthetic process Source: ComplexPortal
Positive regulation of pentose-phosphate shunt Source: ComplexPortal
Positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
Positive regulation of TOR signaling Source: UniProtKB
Regulation of actin cytoskeleton organization Source: UniProtKB
Regulation of GTPase activity Source: Ensembl
TORC1 signaling Source: WormBase
TOR signaling Source: GO_Central

Cytoplasm