MMP23B
This gene (MMP23B) encodes a member of the matrix metalloproteinase (MMP) family, and it is part of a duplicated region of chromosome 1p36.3. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. This gene belongs to the more telomeric copy of the duplicated region. [provided by RefSeq, Jul 2008]
Full Name
Matrix Metallopeptidase 23B
Function
Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity).
Biological Process
Collagen catabolic process Source: GO_Central
Extracellular matrix organization Source: GO_Central
Proteolysis Source: UniProtKB
Reproduction Source: UniProtKB
Extracellular matrix organization Source: GO_Central
Proteolysis Source: UniProtKB
Reproduction Source: UniProtKB
Cellular Location
Endoplasmic reticulum
Endoplasmic reticulum membrane
Other locations
Membrane
Note: A secreted form produced by proteolytic cleavage may also exist.
Endoplasmic reticulum membrane
Other locations
Membrane
Note: A secreted form produced by proteolytic cleavage may also exist.
Topology
Cytoplasmic: 1-19
Helical: 20-40
Lumenal: 41-390
Helical: 20-40
Lumenal: 41-390
PTM
N-glycosylated.
Proteolytic cleavage might yield an active form.
Proteolytic cleavage might yield an active form.
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Anti-MMP23B antibodies
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Target: MMP23B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1D8
Application*: SE, E
Target: MMP23B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-2392
Application*: E
Target: MMP23B
Host: Mouse
Specificity: Human
Clone: CBFYM-2391
Application*: WB, IC, P, C, E
Target: MMP23B
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: A1148
Application*: ICC, IHC, IP, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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