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MYF6

The protein encoded by this gene is a probable basic helix-loop-helix (bHLH) DNA binding protein involved in muscle differentiation. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of autosomal dominant centronuclear myopathy (ADCNM).

Full Name

myogenic factor 6 (herculin)

Function

Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.

Biological Process

Muscle cell fate commitment Source: BHF-UCL
Muscle tissue morphogenesis Source: Ensembl
Negative regulation of transcription, DNA-templated Source: Ensembl
Positive regulation of myoblast differentiation Source: GO_Central
Positive regulation of skeletal muscle fiber development Source: GO_Central
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Skeletal muscle cell differentiation Source: GO_Central
Skeletal muscle tissue development Source: ProtInc
Somitogenesis Source: Ensembl

Cellular Location

Nucleus

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Anti-MYF6 antibodies

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Mouse Anti-MYF6 Recombinant Antibody (CBT3116) (V2LY-0625-LY2750)

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Target: MYF6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT3116

Application*: WB

Mouse Anti-MYF6 Recombinant Antibody (CBFYM-2910) (CBMAB-M3105-FY)

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Target: MYF6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-2910

Application*: E, WB

Mouse Anti-MYF6 Recombinant Antibody (CBFYM-0765) (CBMAB-M0908-FY)

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Target: MYF6

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYM-0765

Application*: E, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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