Mouse Anti-MYF6 Recombinant Antibody (CBFYM-0765) (CBMAB-M0908-FY)

Name: Mouse Anti-MYF6 Recombinant Antibody (CBFYM-0765)
SKU: CBMAB-M0908-FY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYM-0765

Antibody Isotype

IgG2a, k

Application

ELISA, WB

Basic Information

Specificity

Human

Antibody Isotype

IgG2a, k

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Introduction

The protein encoded by this gene is a probable basic helix-loop-helix DNA binding protein involved in muscle differentiation. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of autosomal dominant centronuclear myopathy.

Entrez Gene ID

4618

UniProt ID

P23409

Alternative Names

Myogenic Factor 6; Muscle-Specific Regulatory Factor 4; Class C Basic Helix-Loop-Helix Protein 4; Myogenic Factor 6 (Herculin); BHLHc4; Myf-6; MRF4; Herculin; CNM3

Function

Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.

Biological Process

Muscle cell fate commitment Source: BHF-UCL
Muscle tissue morphogenesis Source: Ensembl
Negative regulation of transcription, DNA-templated Source: Ensembl
Positive regulation of myoblast differentiation Source: GO_Central
Positive regulation of skeletal muscle fiber development Source: GO_Central
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Skeletal muscle cell differentiation Source: GO_Central
Skeletal muscle tissue development Source: ProtInc
Somitogenesis Source: Ensembl

Cellular Location

Nucleus

More Infomation

References

Li, F., Yang, C., Xie, Y., Gao, X., Zhang, Y., Ning, H., ... & Shan, A. (2022). Maternal nutrition altered embryonic MYOD1, MYF5, and MYF6 gene expression in genetically fat and lean lines of chickens. Animal Bioscience, 35(8), 1223.

Arons, E., Zhou, H., Sokolsky, M., Gorelik, D., Potocka, K., Davies, S., ... & Kreitman, R. J. (2020). Expression of the muscle-associated gene MYF6 in hairy cell leukemia. Plos one, 15(2), e0227586.

Lazure, F., Blackburn, D. M., Corchado, A. H., Sahinyan, K., Karam, N., Sharanek, A., ... & Soleimani, V. D. (2020). Myf6/MRF4 is a myogenic niche regulator required for the maintenance of the muscle stem cell pool. EMBO reports, 21(12), e49499.

Zhang, X., Chen, M., Liu, X., Zhang, L., Ding, X., Guo, Y., ... & Guo, H. (2020). A novel lncRNA, lnc403, involved in bovine skeletal muscle myogenesis by mediating KRAS/Myf6. Gene, 751, 144706.

Rajesh, M., Kamalam, B. S., Ciji, A., Akhtar, M. S., Pandey, N., Gupta, S., ... & Singh, A. K. (2019). Molecular characterisation and transcriptional regulation of muscle growth regulatory factors myogenin and myogenic factor 6 in the Trans-Himalayan cyprinid fish Schizothorax richardsonii. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 231, 188-200.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-MYF6 Recombinant Antibody (CBFYM-2910) (CAT#: CBMAB-M3105-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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