NCL

Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20. [provided by RefSeq, Jul 2008]
Full Name
Nucleolin
Function
Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.
Biological Process
Angiogenesis Source: UniProtKB
Cellular response to epidermal growth factor stimulus Source: Ensembl
Cellular response to leukemia inhibitory factor Source: Ensembl
Negative regulation of translation Source: CAFA
Positive regulation of mRNA splicing, via spliceosome Source: GO_Central
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I Source: UniProtKB
Cellular Location
Nucleus
nucleolus
Cytoplasm
Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
PTM
Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group (By similarity).
Symmetrically methylated by PRMT5.
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Anti-NCL antibodies

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Mouse Anti-NCL Recombinant Antibody (E5M7K) (CBMAB-CP1775-LY)

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Target: NCL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: E5M7K
Application*: WB, IF (IC)
Datasheet SDS

Mouse Anti-NCL Recombinant Antibody (CBWJC-4240) (CBMAB-C5595WJ)

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Target: NCL
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CBWJC-4240
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-NCL Recombinant Antibody (ZN004) (CBMAB-N1428-WJ)

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Target: NCL
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse
Clone: ZN004
Application*: E, F, IC, IF, WB
Datasheet SDS

Rabbit Anti-NCL Recombinant Antibody (D4C7O) (CBMAB-N1424-WJ)

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Target: NCL
Host: Rabbit
Specificity: Human, Mouse, Rat, Monkey
Clone: D4C7O
Application*: WB, IP, IF, F
Datasheet SDS

Mouse Anti-NCL Recombinant Antibody (10C7) (CBMAB-N1422-WJ)

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Target: NCL
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: 10C7
Application*: WB, IH
Datasheet SDS

Mouse Anti-NCL Recombinant Antibody (4E2) (CBMAB-N1419-WJ)

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Target: NCL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4E2
Application*: F, IC, IH, WB
Datasheet SDS

Mouse Anti-NCL Recombinant Antibody (CBWJN-0890) (CBMAB-N0178-WJ)

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Target: NCL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJN-0890
Application*: WB, F, P, IF
Datasheet SDS

Mouse Anti-NCL Recombinant Antibody (CBWJN-0745) (CBMAB-N0177-WJ)

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Target: NCL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBWJN-0745
Application*: F, P, WB, IF
Datasheet SDS

Mouse Anti-NCL Recombinant Antibody (CBWJN-0730) (CBMAB-N0176-WJ)

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Target: NCL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJN-0730
Application*: WB, F, P, IF, MC
Datasheet SDS

Rabbit Anti-NCL Recombinant Antibody (CBWJN-0954) (CBMAB-N0175-WJ)

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Target: NCL
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBWJN-0954
Application*: WB, P, IC
Datasheet SDS

Mouse Anti-NCL Recombinant Antibody (CBWJN-0424) (CBMAB-N0174-WJ)

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Target: NCL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Dog, Human, Monkey
Clone: CBWJN-0424
Application*: E, IC, IP, WB
Datasheet SDS

Mouse Anti-NCL Recombinant Antibody (CBWJN-0361) (CBMAB-N0173-WJ)

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Target: NCL
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJN-0361
Application*: WB, F, P, IF, MC
Datasheet SDS

Mouse Anti-NCL Recombinant Antibody (CBWJN-0360) (CBMAB-N0172-WJ)

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Target: NCL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJN-0360
Application*: WB, F, P, IF, MC
Datasheet SDS

Mouse Anti-NCL Recombinant Antibody (130CT43.8.5) (CBMAB-N0171-WJ)

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Target: NCL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 130CT43.8.5
Application*: E, IF, IH, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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