NEFM
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Full Name
Neurofilament Medium
Function
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity).
Biological Process
Neurofilament bundle assembly Source: BHF-UCL
Cellular Location
Cytoskeleton
Other locations
axon
Other locations
axon
PTM
There are a number of repeats of the tripeptide K-S-P, NFM is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFM results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber.
Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincidentally with a change in the neurofilament function.
Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization.
Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincidentally with a change in the neurofilament function.
Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization.
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Anti-NEFM antibodies
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CompareTarget: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken, Human, Mouse, Rat
Clone: 4E162
Application*: WB, IC
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: A1318
Application*: ELISA, IHC, WB
Target: NEFM
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat, Cattle, Chicken, Horse, Human, Mouse, Pig
Application*: IF, IHC, WB
Target: NEFM
Host: Mouse
Specificity: Frog, Guinea pig, Hamster, Human, Monkey, Rabbit
Clone: CBWJN-0866
Application*: WB, IH, F
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0857
Application*: C, WB
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Leech, Rat
Clone: CBWJN-0799
Application*: IC, IF, IH, IP, WB
Target: NEFM
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBWJN-0798
Application*: IF, IH, IP, WB
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBWJN-0796
Application*: E, IF, IH, WB
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Human, Rat
Clone: CBWJN-0739
Application*: C, P, WB
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle
Clone: CBWJN-0703
Application*: IH
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBWJN-0651
Application*: WB
Target: NEFM
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Mouse, Rat, Hamster, Cattle, Human, Monkey
Clone: LB-961
Application*: WB, C, IC
Target: NEFM
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJN-1311
Application*: WB, IH, IP
Target: NEFM
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBWJN-0836
Application*: WB, F, IP
Target: NEFM
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJN-0828
Application*: IC, IH, IP, WB
Target: NEFM
Host: Mouse
Specificity: Human, Mouse, Rat
Clone: E-9
Application*: WB, IP, IF, E
Target: NEFM
Host: Mouse
Antibody Isotype: IgG
Specificity: Chicken, Human, Mouse, Rat
Clone: CBWJN-0489
Application*: IC, IH, WB
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 6H9
Application*: IF, WB
Target: NEFM
Host: Mouse
Antibody Isotype: IgG
Specificity: Cattle, Human, Rat
Clone: 5H52
Application*: WB, IC, F
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5H4
Application*: WB
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5B7
Application*: WB, IH
Target: NEFM
Host: Mouse
Specificity: Human, Rat
Clone: 4H360
Application*: IH, WB
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Cattle, Hamster, Human, Mouse, Rabbit, Rat
Clone: CBWJN-0374
Application*: E, IH, IP, WB
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: CBWJN-0373
Application*: E, F, IH, IP, WB
Target: NEFM
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Rat
Clone: CBWJN-0371
Application*: E, IH, IP
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken, Human, Mouse, Pig, Rat
Clone: CBWJN-0370
Application*: E, IF, IH, WB
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Avian, Human, Pig
Clone: 3C163
Application*: E, WB
Target: NEFM
Host: Mouse
Antibody Isotype: IgG
Specificity: Avian, Rat
Clone: CBWJN-0012
Application*: WB, IH
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Chicken, Rat
Clone: CBWJN-0009
Application*: E, F, IC, IF, IH, WB
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2G3
Application*: WB, IH
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2G12
Application*: WB, F, E, MC
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 2E3B12
Application*: E, IH, WB
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A4
Application*: WB, IF
Target: NEFM
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Pig
Clone: 1A3C7
Application*: E, IF, IH, WB
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat
Clone: CBWJN-0169
Application*: IF, IH, WB
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-1310
Application*: WB
Target: NEFM
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CBWJN-1309
Application*: WB, IH
Target: NEFM
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: CBWJN-1308
Application*: WB, IH
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBWJN-1307
Application*: WB, IH, P
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBWJN-1306
Application*: WB, IH, IF
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-1305
Application*: C, P
Target: NEFM
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBWJN-1304
Application*: P, C
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Hamster, Frog
Clone: CBWJN-0860
Application*: WB, IH, P, C
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4170
Application*: IC, F
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4685
Application*: WB, F
Target: NEFM
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 2E30
Application*: WB, C
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle
Clone: RNF406
Application*: C, P, WB
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Zebrafish, Leptospirosis
Clone: RMO44
Application*: WB, E, P, C, IC/IF, IH
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle
Clone: NF403
Application*: IH, WB
Target: NEFM
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat, Cattle, Cat, Pig
Clone: NF-09
Application*: WB, E, P, C, IC/IF, IH
Target: NEFM
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EP2460
Application*: WB, IP, P, IC/IF
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 3H11
Application*: WB, C, P, IC/IF
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken, Avian
Clone: 4H6
Application*: IF, IH, WB
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Human, Mouse
Clone: 2H3
Application*: IF, IH, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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