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NGEF

Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin t
Full Name
neuronal guanine nucleotide exchange factor
Function
Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).
Biological Process
Activation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Cell differentiationIEA:UniProtKB-KW
Ephrin receptor signaling pathwayISS:UniProtKB
Negative regulation of dendritic spine morphogenesisISS:UniProtKB
Nervous system developmentIEA:UniProtKB-KW
Regulation of GTPase activityISS:UniProtKB
Regulation of small GTPase mediated signal transductionTAS:Reactome
Cellular Location
Activation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Cell differentiationIEA:UniProtKB-KW
Ephrin receptor signaling pathwayISS:UniProtKB
Negative regulation of dendritic spine morphogenesisISS:UniProtKB
Nervous system developmentIEA:UniProtKB-KW
Regulation of GTPase activityISS:UniProtKB
Regulation of small GTPase mediated signal transductionTAS:Reactome
PTM
Src-dependent phosphorylation at Tyr-179 upon EPHA4 activation increases the guanine exchange factor activity toward RHOA. Phosphorylation by CDK5 upon EPHA4 activation by EFNA1 may regulate dendritic spine morphogenesis (By similarity).
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Anti-NGEF antibodies

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Mouse Anti-NGEF Recombinant Antibody (6E7) (CBMAB-N2345-WJ)

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Target: NGEF
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 6E7
Application*: E, WB
Datasheet SDS
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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