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NME1

This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008]

Full Name

NME/NM23 Nucleoside Diphosphate Kinase 1

Function

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.

Biological Process

Cell differentiationIEA:UniProtKB-KW
CTP biosynthetic processIEA:InterPro
EndocytosisIEA:UniProtKB-KW
GTP biosynthetic processIEA:InterPro
LactationIEA:Ensembl
Negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:UniProtKB
Nervous system developmentIEA:UniProtKB-KW
Positive regulation of DNA bindingManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of epithelial cell proliferationManual Assertion Based On ExperimentIMP:HGNC-UCL
Regulation of apoptotic processManual Assertion Based On ExperimentTAS:UniProtKB
UTP biosynthetic processIEA:InterPro

Cellular Location

Cytoplasm
Nucleus
Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA.

Anti-NME1 antibodies

Mouse Anti-NME1 Recombinant Antibody (CBWJN-1450) (CBMAB-N2769-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat, Monkey, Dog

Clone: CBWJN-1450

Application*: IH, IF

Mouse Anti-NME1 Recombinant Antibody (CBWJN-1448) (CBMAB-N2767-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat, Dog

Clone: CBWJN-1448

Application*: IH, IF

Mouse Anti-NME1 Recombinant Antibody (CBWJN-1447) (CBMAB-N2766-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Rat, Monkey, Dog

Clone: CBWJN-1447

Application*: IH, IF

Mouse Anti-NME1 Recombinant Antibody (KM1121) (CBMAB-N2765-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat

Clone: KM1121

Application*: IH, WB

Rabbit Anti-NME1 Recombinant Antibody (D14H1) (CBMAB-N2761-WJ)

SDS

Target: NME1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Monkey, Cattle

Clone: D14H1

Application*: WB

Mouse Anti-NME1 Recombinant Antibody (C-8) (CBMAB-N2760-WJ)

SDS

Target: NME1

Host: Mouse

Specificity: Human

Clone: C-8

Application*: WB, IP, IF, E

Mouse Anti-NME1 Recombinant Antibody (7F4) (CBMAB-N2758-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 7F4

Application*: P, WB

Mouse Anti-NME1 Recombinant Antibody (7F2) (CBMAB-N2757-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 7F2

Application*: WB, IH

Mouse Anti-NME1 Recombinant Antibody (7A1) (CBMAB-N2756-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 7A1

Application*: P, WB

Mouse Anti-NME1 Recombinant Antibody (6A11) (CBMAB-N2754-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 6A11

Application*: P, WB

Mouse Anti-NME1 Recombinant Antibody (5F4) (CBMAB-N2753-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 5F4

Application*: WB, E, IF

Mouse Anti-NME1 Recombinant Antibody (4H2) (CBMAB-N2752-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 4H2

Application*: WB, IH

Mouse Anti-NME1 Recombinant Antibody (4G3) (CBMAB-N2751-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 4G3

Application*: P, WB

Mouse Anti-NME1 Recombinant Antibody (4F11) (CBMAB-N2750-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 4F11

Application*: WB

Mouse Anti-NME1 Recombinant Antibody (2A5) (CBMAB-N2745-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 2A5

Application*: P, WB

Mouse Anti-NME1 Recombinant Antibody (25D8) (CBMAB-N2744-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 25D8

Application*: P, WB

Mouse Anti-NME1 Recombinant Antibody (24A2) (CBMAB-N2743-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 24A2

Application*: P, WB

Mouse Anti-NME1 Recombinant Antibody (22F6) (CBMAB-N2742-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 22F6

Application*: WB

Mouse Anti-NME1 Recombinant Antibody (22F10)-IgG1 (CBMAB-N2740-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 22F10

Application*: E

Mouse Anti-NME1 Recombinant Antibody (1H4) (CBMAB-N2738-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 1H4

Application*: P, WB

Mouse Anti-NME1 Recombinant Antibody (1D12) (CBMAB-N2737-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 1D12

Application*: P, WB

Mouse Anti-NME1 Recombinant Antibody (1C11) (CBMAB-N2735-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1C11

Application*: P, WB

Mouse Anti-NME1 Recombinant Antibody (1A12)-IgG1 (CBMAB-N2733-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1A12

Application*: E

Mouse Anti-NME1 Recombinant Antibody (18C12) (CBMAB-N2732-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 18C12

Application*: WB

Mouse Anti-NME1 Recombinant Antibody (CBWJN-0189) (CBMAB-N2731-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJN-0189

Application*: E, IF, WB

Mouse Anti-NME1 Recombinant Antibody (CBWJN-0145) (CBMAB-N2730-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJN-0145

Application*: E, F, IH, WB

Rabbit Anti-NME1 Recombinant Antibody (11H2L6) (CBMAB-N2728-WJ)

SDS

Target: NME1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: 11H2L6

Application*: F, IC, IF, WB

Mouse Anti-NME1 Recombinant Antibody (CBWJN-0079) (CBMAB-N2727-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBWJN-0079

Application*: E, IF, WB

Mouse Anti-NME1 Recombinant Antibody (CBWJN-0055) (CBMAB-N2726-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBWJN-0055

Application*: WB

Mouse Anti-NME1 Recombinant Antibody (6E8) (CBMAB-N2724-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 6E8

Application*: WB, IH

Mouse Anti-NME1 Recombinant Antibody (7E5) (CBMAB-N2723-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 7E5

Application*: P, WB

Mouse Anti-NME1 Recombinant Antibody (CBWJN-1444) (CBMAB-N2722-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse, Rat

Clone: CBWJN-1444

Application*: WB

Mouse Anti-NME1 Recombinant Antibody (CBWJN-1443) (CBMAB-N2721-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBWJN-1443

Application*: WB

Mouse Anti-NME1 Recombinant Antibody (CBWJN-1442) (CBMAB-N2720-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBWJN-1442

Application*: P

Mouse Anti-NME1 Recombinant Antibody (22E1) (CBMAB-N2719-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 22E1

Application*: WB

Rabbit Anti-NME1 Recombinant Antibody (CBWJN-1441) (CBMAB-N2718-WJ)

SDS

Target: NME1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBWJN-1441

Application*: P

Mouse Anti-NME1 Recombinant Antibody (7D6) (CBMAB-N0426-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 7D6

Application*: E

Mouse Anti-NME1 Recombinant Antibody (4B2)-IgG1 (CBMAB-N0425-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 4B2

Application*: F, E, IC, P, WB

Mouse Anti-NME1 Recombinant Antibody (1D7) (CBMAB-N0424-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1D7

Application*: E, IF, IH, IP, WB

Mouse Anti-NME1 Recombinant Antibody (1172CT2.4.1.1) (CBMAB-N0423-WJ)

SDS

Target: NME1

Host: Mouse

Specificity: Human, Rat

Clone: 1172CT2.4.1.1

Application*: WB, P

Mouse Anti-NME1 Recombinant Antibody (CBWJN-1003) (CBMAB-N0422-WJ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBWJN-1003

Application*: F

Mouse Anti-NME1 Antibody (9BA18) (CBMAB-1461CQ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 9BA18

Application*: E, WB

Mouse Anti-NME1 Antibody (9BA16) (CBMAB-1459CQ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 9BA16

Application*: E, P, IH, M, WB

Mouse Anti-NME1 Antibody (9BA15) (CBMAB-1458CQ)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 9BA15

Application*: E, WB

Mouse Anti-NME1 Recombinant Antibody (2H1) (CBMAB-A6012-LY)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2H1

Application*: WB, E

Mouse Anti-NME1 Recombinant Antibody (A1376) (CBMAB-AP12673LY)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Rat

Clone: A1376

Application*: IHC, WB

Mouse Anti-NME1 Recombinant Antibody (4B2) (CBMAB-AO804LY)

SDS

Target: NME1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 4B2

Application*: WB, IF

NME1 Matched Antibody Pair (803) (APMAB-803LY)

SDS

Target: NME1

Specificity: Human

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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