NME1
This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008]
Full Name
NME/NM23 Nucleoside Diphosphate Kinase 1
Function
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.
Biological Process
Cell differentiationIEA:UniProtKB-KW
CTP biosynthetic processIEA:InterPro
EndocytosisIEA:UniProtKB-KW
GTP biosynthetic processIEA:InterPro
LactationIEA:Ensembl
Negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:UniProtKB
Nervous system developmentIEA:UniProtKB-KW
Positive regulation of DNA bindingManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of epithelial cell proliferationManual Assertion Based On ExperimentIMP:HGNC-UCL
Regulation of apoptotic processManual Assertion Based On ExperimentTAS:UniProtKB
UTP biosynthetic processIEA:InterPro
CTP biosynthetic processIEA:InterPro
EndocytosisIEA:UniProtKB-KW
GTP biosynthetic processIEA:InterPro
LactationIEA:Ensembl
Negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:UniProtKB
Nervous system developmentIEA:UniProtKB-KW
Positive regulation of DNA bindingManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of epithelial cell proliferationManual Assertion Based On ExperimentIMP:HGNC-UCL
Regulation of apoptotic processManual Assertion Based On ExperimentTAS:UniProtKB
UTP biosynthetic processIEA:InterPro
Cellular Location
Cytoplasm
Nucleus
Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA.
Nucleus
Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA.
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Anti-NME1 antibodies
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CompareTarget: NME1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 22F10
Application*: E
Target: NME1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 9BA15
Application*: E, WB
Target: NME1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2H1
Application*: WB, E
Target: NME1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT946
Application*: WB, P, IF, IC, F, E
Target: NME1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3259
Application*: IH, IC, F
Target: NME1
Specificity: Human
Target: NME1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: A1376
Application*: IHC, WB
Target: NME1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4B2
Application*: WB, IF
Target: NME1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Monkey, Dog
Clone: CBWJN-1450
Application*: IH, IF
Target: NME1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Dog
Clone: CBWJN-1448
Application*: IH, IF
Target: NME1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Rat, Monkey, Dog
Clone: CBWJN-1447
Application*: IH, IF
Target: NME1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: KM1121
Application*: IH, WB
Target: NME1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey, Cattle
Clone: D14H1
Application*: WB
Target: NME1
Host: Mouse
Specificity: Human
Clone: C-8
Application*: WB, IP, IF, E
Target: NME1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 7F4
Application*: P, WB
Target: NME1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 7F2
Application*: WB, IH
Target: NME1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 7A1
Application*: P, WB
Target: NME1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6A11
Application*: P, WB
Target: NME1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 5F4
Application*: WB, E, IF
Target: NME1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4H2
Application*: WB, IH
Target: NME1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4G3
Application*: P, WB
Target: NME1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4F11
Application*: WB
Target: NME1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2A5
Application*: P, WB
Target: NME1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 25D8
Application*: P, WB
Target: NME1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 24A2
Application*: P, WB
Target: NME1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 22F6
Application*: WB
Target: NME1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1H4
Application*: P, WB
Target: NME1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1D12
Application*: P, WB
Target: NME1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1C11
Application*: P, WB
Target: NME1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A12
Application*: E
Target: NME1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 18C12
Application*: WB
Target: NME1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0189
Application*: E, IF, WB
Target: NME1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0145
Application*: E, F, IH, WB
Target: NME1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: 11H2L6
Application*: F, IC, IF, WB
Target: NME1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJN-0079
Application*: E, IF, WB
Target: NME1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJN-0055
Application*: WB
Target: NME1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 6E8
Application*: WB, IH
Target: NME1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7E5
Application*: P, WB
Target: NME1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CBWJN-1444
Application*: WB
Target: NME1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJN-1443
Application*: WB
Target: NME1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJN-1442
Application*: P
Target: NME1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 22E1
Application*: WB
Target: NME1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJN-1441
Application*: P
Target: NME1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7D6
Application*: E
Target: NME1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4B2
Application*: F, E, IC, P, WB
Target: NME1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1D7
Application*: E, IF, IH, IP, WB
Target: NME1
Host: Mouse
Specificity: Human, Rat
Clone: 1172CT2.4.1.1
Application*: WB, P
Target: NME1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJN-1003
Application*: F
Target: NME1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 9BA18
Application*: E, WB
Target: NME1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 9BA16
Application*: E, P, IH, M, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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