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Mouse Anti-NME1 Recombinant Antibody (CBT3259) (V2LY-0625-LY2481)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT3259
Antibody Isotype
IgG1
Application
IHC, ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of human NME1 expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ICC1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Preservative
Sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
NME/NM23 Nucleoside Diphosphate Kinase 1
Entrez Gene ID
4830
UniProt ID
P15531
Function
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.
Biological Process
Cell differentiationIEA:UniProtKB-KW
CTP biosynthetic processIEA:InterPro
EndocytosisIEA:UniProtKB-KW
GTP biosynthetic processIEA:InterPro
LactationIEA:Ensembl
Negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:UniProtKB
Nervous system developmentIEA:UniProtKB-KW
Positive regulation of DNA bindingManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of epithelial cell proliferationManual Assertion Based On ExperimentIMP:HGNC-UCL
Regulation of apoptotic processManual Assertion Based On ExperimentTAS:UniProtKB
UTP biosynthetic processIEA:InterPro
Cellular Location
Cytoplasm
Nucleus
Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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