NUDT10

NUDT10 belongs to a subgroup of phosphohydrolases that preferentially attack diphosphoinositol polyphosphates (Hidaka et al., 2002 [PubMed 12105228]).[supplied by OMIM

nudix (nucleoside diphosphate linked moiety X)-type motif 10

Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.

Adenosine 5'-(hexahydrogen pentaphosphate) catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Diadenosine hexaphosphate catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Diadenosine pentaphosphate catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Diphosphoinositol polyphosphate metabolic processManual Assertion Based On ExperimentIBA:GO_Central

Cytoplasm