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PCLAF

PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number.
Full Name
PCNA Clamp Associated Factor
Function
PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number.
Biological Process
Cellular response to DNA damage stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Centrosome cycleManual Assertion Based On ExperimentIMP:UniProtKB
DNA replicationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell cycleManual Assertion Based On ExperimentIMP:UniProtKB
Response to UVManual Assertion Based On ExperimentIDA:UniProtKB
Translesion synthesisManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus
Cytoplasm, perinuclear region
Following DNA damage, localizes to DNA damage sites (PubMed:21628590).
Colocalizes with centrosomes in perinuclear region (PubMed:21673012).
PTM
Monoubiquitinated at Lys-15 and Lys-24 during normal S phase, promoting its association with PCNA. Also diubiquitinated at these 2 sites. Following DNA damage, monoubiquitin chains at Lys-15 and Lys-24 are probably extended, leading to disrupt the interaction with PCNA. Polyubiquitinated by the APC/C complex at the mitotic exit, leading to its degradation by the proteasome.
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Anti-PCLAF antibodies

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Mouse Anti-PCLAF Recombinant Antibody (3C11-1F11) (CBMAB-A4675-LY)

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Target: PCLAF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3C11-1F11
Application*: WB, E
Datasheet SDS

Recombinant Mouse Anti-PCLAF Recombinant Antibody (K11-P1G7) (CBMAB-XB0909-YC)

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Target: PCLAF
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: K11-P1G7
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-PCLAF Recombinant Antibody (K11-P1G7/B8) (CBMAB-P1057-YC)

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Target: PCLAF
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: K11-P1G7/B8
Application*: WB, E, IH
Datasheet SDS

Mouse Anti-PCLAF Recombinant Antibody (3C11-1F11) (CBMAB-K2189-LY)

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Target: PCLAF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3C11-1F11
Application*: E, IF, P, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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