Phospho-RPS6 (Ser235/236)

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Full Name

Ribosomal Protein S6

Function

Component of the 40S small ribosomal subunit (PubMed:8706699).
Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (PubMed:17220279).

Biological Process

Activation-induced cell death of T cellsIEA:Ensembl
Cytoplasmic translation1 PublicationIC:FlyBase
Erythrocyte developmentIEA:Ensembl
G1/S transition of mitotic cell cycleIEA:Ensembl
GastrulationIEA:Ensembl
Glucose homeostasisISS:UniProtKB
Mammalian oogenesis stageIEA:Ensembl
Negative regulation of apoptotic processIEA:Ensembl
Placenta developmentIEA:Ensembl
Positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Ribosomal small subunit biogenesisManual Assertion Based On ExperimentIMP:UniProtKB
rRNA processingManual Assertion Based On ExperimentIMP:UniProtKB
T cell differentiation in thymusIEA:Ensembl
T cell proliferation involved in immune responseIEA:Ensembl
TOR signalingManual Assertion Based On ExperimentIDA:UniProtKB
Translation2 PublicationsIC:UniProtKB

Cellular Location

cell body
cytoplasm
cytoplasmic ribonucleoprotein granule
cytosol
cytosolic ribosome
cytosolic small ribosomal subunit
dendrite
endoplasmic reticulum
membrane
nucleolus
nucleoplasm
nucleus
perinuclear region of cytoplasm
polysome
ribonucleoprotein complex
small ribosomal subunit

PTM

Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. Phosphorylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the assembly of the pre-initiation complex.
Specifically hydroxylated (with R stereochemistry) at C-3 of Arg-137 by KDM8.