PI3
This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines.
Full Name
Peptidase Inhibitor 3
Alternative Names
ESI; WAP3; SKALP; WFDC14; cementoin
Function
Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1).
Biological Process
Antibacterial humoral
Copulation
Innate immune response
Peptide cross-linking
Copulation
Innate immune response
Peptide cross-linking
Cellular Location
Secreted
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Anti-PI3 antibodies
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CompareTarget: PI3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb156
Application*: IH, E
Target: PI3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBHb155
Application*: WB, IP, IF, E
Target: PI3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3G9
Application*: WB, E
Target: PI3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3C4
Application*: WB, E
Target: PI3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: TRAB2F
Application*: IA, P, WB
Target: PI3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYA-0098
Application*: IA, P, WB
Target: PI3
Host: Mouse
Specificity: Human
Clone: CBXS-0053
Application*: WB, IC, P, C, E
Target: PI3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYC-P366
Application*: E, IC, WB
Target: PI3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYC-P365
Application*: WB, IP, WB, E
Target: PI3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: TRAB2O
Application*: E, P, WB
Target: PI3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2G20
Application*: E, IP, WB
Target: PI3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1550
Application*: WB
Target: PI3
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1549
Application*: WB
Target: PI3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYE-1595
Application*: WB, E, P
Target: PI3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYE-1594
Application*: WB
Target: PI3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYE-1593
Application*: E, WB
Target: PI3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-1591
Application*: E, WB, IH
Target: PI3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYE-1590
Application*: E, WB, IH
Target: PI3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-1589
Application*: WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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