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PI3

This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq]

Full Name

peptidase inhibitor 3, skin-derived

Function

Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1) (PubMed:29483648).

Biological Process

Antibacterial humoral responseManual Assertion Based On ExperimentIBA:GO_Central
CopulationIEA:InterPro
Innate immune responseManual Assertion Based On ExperimentIBA:GO_Central
Peptide cross-linkingManual Assertion Based On ExperimentIDA:CAFA

Cellular Location

Secreted

Anti-PI3 antibodies

Mouse Anti-PI3 Recombinant Antibody (2G20) (CBMAB-P1727-YC)

SDS

Target: PI3

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2G20

Application*: E, IP, WB

Mouse Anti-PI3 Recombinant Antibody (TRAB2O) (CBMAB-P1729-YC)

SDS

Target: PI3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: TRAB2O

Application*: E, P, WB

Mouse Anti-PI3 Recombinant Antibody (CBYC-P365) (CBMAB-P1730-YC)

SDS

Target: PI3

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYC-P365

Application*: WB, IP, WB, E

Mouse Anti-PI3 Recombinant Antibody (CBYC-P366) (CBMAB-P1731-YC)

SDS

Target: PI3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYC-P366

Application*: E, IC, WB

Mouse Anti-PI3 Recombinant Antibody (3C4) (CBMAB-A6652-LY)

SDS

Target: PI3

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3C4

Application*: WB, E

Mouse Anti-PI3 Recombinant Antibody (3G9) (CBMAB-A6653-LY)

SDS

Target: PI3

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 3G9

Application*: WB, E

Mouse Anti-PI3 (C-terminus) Recombinant Antibody (CBFYE-1590) (CBMAB-E2247-FY)

SDS

Target: PI3

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYE-1590

Application*: E, WB, IH

Mouse Anti-PI3 (C-terminus) Recombinant Antibody (CBFYE-1591) (CBMAB-E2248-FY)

SDS

Target: PI3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYE-1591

Application*: E, WB, IH

Mouse Anti-PI3 (AA 1-118) Recombinant Antibody (CBFYE-1593) (CBMAB-E2250-FY)

SDS

Target: PI3

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYE-1593

Application*: E, WB

Rabbit Anti-PI3 Recombinant Antibody (CBFYE-1594) (CBMAB-E2251-FY)

SDS

Target: PI3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBFYE-1594

Application*: WB

Mouse Anti-PI3 Recombinant Antibody (CBFYE-1595) (CBMAB-E2252-FY)

SDS

Target: PI3

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYE-1595

Application*: WB, E, P

Rat Anti-PI3 Recombinant Antibody (CBYJT-1549) (CBMAB-T0584-YJ)

SDS

Target: PI3

Host: Rat

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-1549

Application*: WB

Mouse Anti-PI3 Recombinant Antibody (CBYJT-1550) (CBMAB-T0585-YJ)

SDS

Target: PI3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-1550

Application*: WB

Mouse Anti-PI3 Recombinant Antibody (CBXS-0053) (CBMAB-S3054-CQ)

SDS

Target: PI3

Host: Mouse

Specificity: Human

Clone: CBXS-0053

Application*: WB, IC, P, C, E

Mouse Anti-PI3 Recombinant Antibody (CBFYA-0098) (CBMAB-X0141-FY)

SDS

Target: PI3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYA-0098

Application*: IA, P, WB

Mouse Anti-PI3 Recombinant Antibody (TRAB2F) (CBMAB-X0142-FY)

SDS

Target: PI3

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: TRAB2F

Application*: IA, P, WB

Mouse Anti-PI3 Recombinant Antibody (CBFYE-1589) (CBMAB-E2246-FY)

SDS

Target: PI3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYE-1589

Application*: WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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