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Mouse Anti-PI3 Recombinant Antibody (3C4) (CBMAB-A6652-LY)

The product is antibody recognizes PI3. The antibody 3C4 immunoassay techniques such as: WB, ELISA.
See all PI3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3C4
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
PI3 (AAH10952, 1 a.a. ~ 117 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
peptidase inhibitor 3, skin-derived
Introduction
This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq]
Entrez Gene ID
5266
UniProt ID
P19957
Alternative Names
ESI; MGC13613; SKALP; WAP3; WFDC14; cementoin
Function
Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1) (PubMed:29483648).
Biological Process
Antibacterial humoral responseManual Assertion Based On ExperimentIBA:GO_Central
CopulationIEA:InterPro
Innate immune responseManual Assertion Based On ExperimentIBA:GO_Central
Peptide cross-linkingManual Assertion Based On ExperimentIDA:CAFA
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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