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Mouse Anti-PI3 Recombinant Antibody (CBFYE-1589) (CBMAB-E2246-FY)

This product is mouse antibody that recognizes PI3. The antibody CBFYE-1589 can be used for immunoassay techniques such as: WB.
See all PI3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-1589
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Recognizes human leukocyte elastase
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% BSA
Preservative
0.02% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
peptidase inhibitor 3, skin-derived
Introduction
This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines.
Entrez Gene ID
5266
UniProt ID
P19957
Alternative Names
Peptidase Inhibitor 3; Skin-Derived Antileukoproteinase; Protease Inhibitor 3, Skin-Derived (SKALP); WAP Four-Disulfide Core Domain Protein 14; Peptidase Inhibitor 3, Skin-Derived; Elastase-Specific Inhibitor; Protease Inhibitor WAP3; Trappin-2; WFDC14
Function
Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1) (PubMed:29483648).
Biological Process
Antibacterial humoral responseManual Assertion Based On ExperimentIBA:GO_Central
CopulationIEA:InterPro
Innate immune responseManual Assertion Based On ExperimentIBA:GO_Central
Peptide cross-linkingManual Assertion Based On ExperimentIDA:CAFA
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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