RGS14

This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq]

regulator of G-protein signaling 14

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o)-alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory.

Biological Process cell divisionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process chromosome segregationISS:UniProtKB
Biological Process G protein-coupled receptor signaling pathwayTAS:Reactome
Biological Process intracellular signal transductionIEA:InterPro
Biological Process learningISS:UniProtKB
Biological Process long-term memoryISS:UniProtKB
Biological Process long-term synaptic potentiationISS:UniProtKB
Biological Process mitotic cell cycleIEA:Ensembl
Biological Process negative regulation of ERK1 and ERK2 cascadeISS:UniProtKB
Biological Process negative regulation of G protein-coupled receptor signaling pathwayISS:UniProtKB
Biological Process negative regulation of MAP kinase activityISS:UniProtKB
Biological Process negative regulation of synaptic plasticityISS:UniProtKB
Biological Process nucleocytoplasmic transportISS:UniProtKB
Biological Process platelet-derived growth factor receptor signaling pathwayISS:UniProtKB
Biological Process positive regulation of GTPase activityIEA:Ensembl
Biological Process positive regulation of neurogenesisISS:UniProtKB
Biological Process regulation of DNA-templated transcription in response to stressISS:UniProtKB
Biological Process regulation of G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process response to oxidative stressISS:UniProtKB
Biological Process spindle organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process visual learningISS:UniProtKB
Biological Process zygote asymmetric cell divisionISS:UniProtKB

Nucleus
Nucleus, PML body
Cytoplasm
Membrane
Cell membrane
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm, cytoskeleton, spindle
Cytoplasm, cytoskeleton, spindle pole
Cell projection, dendrite
Cell projection, dendritic spine
Postsynaptic density
Associates with the perinuclear sheaths of microtubules (MTs) surrounding the pronuclei, prior to segregating to the anastral mitotic apparatus and subsequently the barrel-shaped cytoplasmic bridge between the nascent nuclei of the emerging 2-cell embryo. Localizes to a perinuclear compartment near the microtubule-organizing center (MTOC). Expressed in the nucleus during interphase and segregates to the centrosomes and astral MTs during mitosis. Relocalizes to the nucleus in PML nuclear bodies in response to heat stress. Colocalizes with RIC8A in CA2 hippocampal neurons. Localizes to spindle poles during metaphase. Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner. Recruited from the cytosol to the plasma membrane by the inactive GDP-bound forms of G(i) alpha subunits GNAI1 and GNAI3. Recruited from the cytosol to membranes by the active GTP-bound form of HRAS. Colocalizes with G(i) alpha subunit GNAI1 and RIC8A at the plasma membrane. Colocalizes with BRAF and RAF1 in both the cytoplasm and membranes (By similarity).

Phosphorylated by PKC. Phosphorylation is increased in presence of forskolin and may enhance the GDI activity on G(i) alpha subunit GNAI1 (By similarity).