RND2

This gene encodes a member of the Rho GTPase family, whose members play a key role in the regulation of actin cytoskeleton organization in response to extracellular growth factors. This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking. The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1. [provided by RefSeq]

Full Name

Rho family GTPase 2

Function

May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily (By similarity).

Biological Process

Biological Process actin filament organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process collateral sproutingIEA:Ensembl
Biological Process cortical cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process establishment or maintenance of cell polarityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of collateral sproutingIEA:Ensembl
Biological Process regulation of actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of cell shapeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process small GTPase mediated signal transductionIEA:InterPro

Cellular Location

Cytoplasmic vesicle, secretory vesicle, acrosome membrane
Colocalizes with RACGAP1 in Golgi-derived proacrosomal vesicles and the acrosome.