SEMA3C

This gene encodes a secreted glycoprotein that belongs to the semaphorin class 3 family of neuronal guidance cues. The encoded protein contains an N-terminal sema domain, integrin and immunoglobulin-like domains, and a C-terminal basic domain. Homodimerization and proteolytic cleavage of the C-terminal propeptide are necessary for the function of the encoded protein. It binds a neuropilin co-receptor before forming a heterotrimeric complex with an associated plexin. An increase in the expression of this gene correlates with an increase in cancer cell invasion and adhesion. Naturally occurring mutations in this gene are associated with Hirschsprung disease.

Full Name

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C

Function

Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity).

Biological Process

Biological Process axon guidanceISS:UniProtKB
Biological Process blood vessel remodelingIEA:Ensembl
Biological Process cardiac endothelial to mesenchymal transitionIEA:Ensembl
Biological Process cardiac right ventricle morphogenesisIEA:Ensembl
Biological Process dichotomous subdivision of terminal units involved in salivary gland branchingIEA:Ensembl
Biological Process immune responseManual Assertion Based On ExperimentTAS:ProtInc
Biological Process limb bud formationIEA:Ensembl
Biological Process negative chemotaxisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of axon extension involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neural crest cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neural tube developmentIEA:Ensembl
Biological Process outflow tract septum morphogenesisISS:BHF-UCL
Biological Process positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesisISS:BHF-UCL
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process post-embryonic developmentIEA:Ensembl
Biological Process pulmonary myocardium developmentIEA:Ensembl
Biological Process response to xenobiotic stimulusManual Assertion Based On ExperimentTAS:ProtInc
Biological Process semaphorin-plexin signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process somitogenesisIEA:Ensembl

Cellular Location

Secreted