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SERPINB4

The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein is highly expressed in many tumor cells and can inactivate granzyme M, an enzyme that kills tumor cells. This protein, along with serpin B3, can be processed into smaller fragments that aggregate to form an autoantigen in psoriasis, probably by causing chronic inflammation.
Full Name
serpin family B member 4
Function
May act as a protease inhibitor to modulate the host immune response against tumor cells.
Biological Process
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of peptidase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protection from natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of proteolysis1 PublicationNAS:UniProtKB
Cellular Location
Cytoplasm
Seems to also be secreted in plasma by cancerous cells but at a low level.

Anti-SERPINB4 antibodies

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Mouse Anti-SERPINB4 Recombinant Antibody (CBXS-5925) (CBMAB-S0774-CQ)

Datasheet SDS
Target: SERPINB4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5925
Application*: E

Mouse Anti-SERPINB4 Recombinant Antibody (CBXS-5621) (CBMAB-S0499-CQ)

Datasheet SDS
Target: SERPINB4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5621
Application*: E, WB

Mouse Anti-SERPINB4 Recombinant Antibody (CBXS-4179) (CBMAB-S1432-CQ)

Datasheet SDS
Target: SERPINB4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-4179
Application*: WB

Mouse Anti-SERPINB4 Recombinant Antibody (CBXS-4571) (CBMAB-S1811-CQ)

Datasheet SDS
Target: SERPINB4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4571
Application*: E, WB

Mouse Anti-SERPINB4 Recombinant Antibody (CBXS-4659) (CBMAB-S1898-CQ)

Datasheet SDS
Target: SERPINB4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4659
Application*: WB

Mouse Anti-SERPINB4 Recombinant Antibody (CBXS-4998) (CBMAB-S2220-CQ)

Datasheet SDS
Target: SERPINB4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4998
Application*: P, WB

Mouse Anti-SERPINB4 Recombinant Antibody (CBXS-5007) (CBMAB-S2229-CQ)

Datasheet SDS
Target: SERPINB4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5007
Application*: WB, IH, P

Mouse Anti-SERPINB4 Recombinant Antibody (CBXS-5078) (CBMAB-S2299-CQ)

Datasheet SDS
Target: SERPINB4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-5078
Application*: WB

Mouse Anti-SERPINB4 Recombinant Antibody (CBXS-5564) (CBMAB-S2771-CQ)

Datasheet SDS
Target: SERPINB4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5564
Application*: WB, IH, IF

Mouse Anti-SERPINB4 Recombinant Antibody (CBXS-0238) (CBMAB-S3215-CQ)

Datasheet SDS
Target: SERPINB4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0238
Application*: E, WB

Mouse Anti-SERPINB4 (AA 320-390) Recombinant Antibody (CBXS-0239) (CBMAB-S3216-CQ)

Datasheet SDS
Target: SERPINB4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-0239
Application*: E, WB

Mouse Anti-SERPINB4 Recombinant Antibody (CBXS-0240) (CBMAB-S3217-CQ)

Datasheet SDS
Target: SERPINB4
Host: Mouse
Specificity: Human
Clone: CBXS-0240
Application*: WB, IC, P, C, E

Rabbit Anti-SERPINB4 Recombinant Antibody (CBXS-1047) (CBMAB-S3940-CQ)

Datasheet SDS
Target: SERPINB4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1047
Application*: P

Mouse Anti-SERPINB4 Recombinant Antibody (CBXS-4418) (CBMAB-S1660-CQ)

Datasheet SDS
Target: SERPINB4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4418
Application*: WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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