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Rabbit Anti-SERPINB4 Recombinant Antibody (CBXS-1047) (CBMAB-S3940-CQ)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBXS-1047
Antibody Isotype
IgG
Application
IHC-P

Basic Information

Immunogen
Recombinant Human SerpinB4/SCCA2 protein
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
serpin family B member 4
Introduction
The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein is highly expressed in many tumor cells and can inactivate granzyme M, an enzyme that kills tumor cells. This protein, along with serpin B3, can be processed into smaller fragments that aggregate to form an autoantigen in psoriasis, probably by causing chronic inflammation.
Entrez Gene ID
6318
UniProt ID
P48594
Alternative Names
LEUPIN; PI11; SCCA-2; SCCA1; SCCA2
Function
May act as a protease inhibitor to modulate the host immune response against tumor cells.
Biological Process
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of peptidase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protection from natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of proteolysis1 PublicationNAS:UniProtKB
Cellular Location
Cytoplasm
Seems to also be secreted in plasma by cancerous cells but at a low level.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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