SLC26A7

This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in gene structure and protein length yet have markedly different tissue expression patterns. This gene has abundant and specific expression in the kidney. Alternatively spliced transcript variants that encode different isoforms have been described.

Full Name

Solute Carrier Family 26 Member 7

Function

Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion.

Biological Process

Biological Process anion transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process bicarbonate transportBy SimilarityISS:UniProtKB
Biological Process chloride transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process gastric acid secretionIEA:Ensembl
Biological Process ion transportTAS:Reactome
Biological Process oxalate transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process sulfate transportManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Recycling endosome membrane
Expressed in the cytoplasm in recycling endosomes of medullary collecting duct cells and in acid-secreting gastric parietal cells. Targeted to the basolateral membrane in hypertonicity and potassium depletion.