SMU1

SMU1 (SMU1, DNA Replication Regulator And Spliceosomal Factor) is a protein coding gene. Diseases associated with SMU1 include Influenza. An important paralog of this gene is APAF1.

SMU1, DNA Replication Regulator And Spliceosomal Factor

Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:28781166).
Regulates alternative splicing of the HSPG2 pre-mRNA (By similarity).
Required for normal accumulation of IK (PubMed:24945353).
Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity).
(Microbial infection) Required, together with IK, for normal splicing of influenza A virus NS1 pre-mRNA, which is required for the production of the exportin NS2 and for the production of influenza A virus particles. Not required for the production of VSV virus particles.

Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of alternative mRNA splicing, via spliceosomeISS:UniProtKB
Biological Process RNA splicingManual Assertion Based On ExperimentIBA:GO_Central

Cytoplasm
Nucleus
Nucleus speckle
Colocalizes with SRSF1 in nuclear speckles.