SPRY1

SPRY1 (Sprouty RTK Signaling Antagonist 1) is a Protein Coding gene. Diseases associated with SPRY1 include Adrenal Cortical Adenocarcinoma and Legius Syndrome. Among its related pathways are Listeria monocytogenes entry into host cells and MAP Kinase Signaling. An important paralog of this gene is SPRY2.

Full Name

Sprouty RTK Signaling Antagonist 1

Function

Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity).
Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).

Biological Process

Biological Process animal organ developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process bud elongation involved in lung branchingIEA:Ensembl
Biological Process epithelial to mesenchymal transition involved in cardiac fibroblast developmentISS:BHF-UCL
Biological Process ERK1 and ERK2 cascadeIEA:Ensembl
Biological Process establishment of mitotic spindle orientationIEA:Ensembl
Biological Process metanephros developmentIEA:Ensembl
Biological Process negative regulation of cell population proliferationIEA:Ensembl
Biological Process negative regulation of epithelial to mesenchymal transitionISS:UniProtKB
Biological Process negative regulation of ERK1 and ERK2 cascadeISS:UniProtKB
Biological Process negative regulation of fibroblast growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:FlyBase
Biological Process negative regulation of GTPase activityIEA:Ensembl
Biological Process negative regulation of lens fiber cell differentiationISS:UniProtKB
Biological Process negative regulation of MAP kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of neurotrophin TRK receptor signaling pathwayIEA:Ensembl
Biological Process negative regulation of Ras protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of transforming growth factor beta receptor signaling pathwayISS:UniProtKB
Biological Process organ inductionIEA:Ensembl
Biological Process ureteric bud developmentIEA:Ensembl

Cellular Location

Cytoplasm
Membrane
Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).