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Rabbit Anti-SPRY1 Recombinant Antibody (D9V6I) (CBMAB-CP2557-LY)

The product is antibody recognizes SPRY1. The antibody D9V6I immunoassay techniques such as: WB,IP.
See all SPRY1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
D9V6I
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val145 of human Spry1 protein.
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Sprouty RTK Signaling Antagonist 1
Introduction
SPRY1 (Sprouty RTK Signaling Antagonist 1) is a Protein Coding gene. Diseases associated with SPRY1 include Adrenal Cortical Adenocarcinoma and Legius Syndrome. Among its related pathways are Listeria monocytogenes entry into host cells and MAP Kinase Signaling. An important paralog of this gene is SPRY2.
Entrez Gene ID
Human10252
Mouse24063
UniProt ID
HumanO43609
MouseQ9QXV9
Alternative Names
Sprouty RTK Signaling Antagonist 1; Spry-1; Sprouty; Drosophila; Homolog Of; 1 (Antagonist Of FGF Signaling); Sprouty (Drosophila) Homolog 1 (Antagonist Of FGF Signaling); Sprouty Homolog 1; Antagonist Of FGF Signaling (Drosophila); Sprouty Homolog 1; Antagonist Of FGF Signaling; Protein Sprouty Homolog 1; HSPRY1;
Function
Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity).
Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).
Biological Process
Biological Process animal organ developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process bud elongation involved in lung branchingIEA:Ensembl
Biological Process epithelial to mesenchymal transition involved in cardiac fibroblast developmentISS:BHF-UCL
Biological Process ERK1 and ERK2 cascadeIEA:Ensembl
Biological Process establishment of mitotic spindle orientationIEA:Ensembl
Biological Process metanephros developmentIEA:Ensembl
Biological Process negative regulation of cell population proliferationIEA:Ensembl
Biological Process negative regulation of epithelial to mesenchymal transitionISS:UniProtKB
Biological Process negative regulation of ERK1 and ERK2 cascadeISS:UniProtKB
Biological Process negative regulation of fibroblast growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:FlyBase
Biological Process negative regulation of GTPase activityIEA:Ensembl
Biological Process negative regulation of lens fiber cell differentiationISS:UniProtKB
Biological Process negative regulation of MAP kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of neurotrophin TRK receptor signaling pathwayIEA:Ensembl
Biological Process negative regulation of Ras protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of transforming growth factor beta receptor signaling pathwayISS:UniProtKB
Biological Process organ inductionIEA:Ensembl
Biological Process ureteric bud developmentIEA:Ensembl
Cellular Location
Cytoplasm
Membrane
Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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