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Mouse Anti-SPRY1 Recombinant Antibody (CBXS-4941) (CBMAB-S2163-CQ)

This product is a mouse antibody that recognizes SPRY1. The antibody CBXS-4941 can be used for immunoassay techniques such as: WB, IHC-P, S-ELISA.
See all SPRY1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4941
Antibody Isotype
IgG2a
Application
WB, IHC-P, S-ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Sprouty RTK Signaling Antagonist 1
Introduction
SPRY1 (Sprouty RTK Signaling Antagonist 1) is a Protein Coding gene. Diseases associated with SPRY1 include Adrenal Cortical Adenocarcinoma and Legius Syndrome. Among its related pathways are MAP Kinase Signaling and RET signaling. An important paralog of this gene is SPRY2.May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.
Entrez Gene ID
10252
UniProt ID
O43609
Alternative Names
hSPRY1
Function
Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity).
Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).
Biological Process
Biological Process animal organ developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process bud elongation involved in lung branchingIEA:Ensembl
Biological Process epithelial to mesenchymal transition involved in cardiac fibroblast developmentISS:BHF-UCL
Biological Process ERK1 and ERK2 cascadeIEA:Ensembl
Biological Process establishment of mitotic spindle orientationIEA:Ensembl
Biological Process metanephros developmentIEA:Ensembl
Biological Process negative regulation of cell population proliferationIEA:Ensembl
Biological Process negative regulation of epithelial to mesenchymal transitionISS:UniProtKB
Biological Process negative regulation of ERK1 and ERK2 cascadeISS:UniProtKB
Biological Process negative regulation of fibroblast growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:FlyBase
Biological Process negative regulation of GTPase activityIEA:Ensembl
Biological Process negative regulation of lens fiber cell differentiationISS:UniProtKB
Biological Process negative regulation of MAP kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of neurotrophin TRK receptor signaling pathwayIEA:Ensembl
Biological Process negative regulation of Ras protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of transforming growth factor beta receptor signaling pathwayISS:UniProtKB
Biological Process organ inductionIEA:Ensembl
Biological Process ureteric bud developmentIEA:Ensembl
Cellular Location
Cytoplasm
Membrane
Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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