SSC5D

SSC5D (Scavenger Receptor Cysteine Rich Family Member With 5 Domains) is a Protein Coding gene. Diseases associated with SSC5D include Syndromic X-Linked Intellectual Disability Snyder Type. Gene Ontology (GO) annotations related to this gene include scavenger receptor activity and laminin binding. An important paralog of this gene is DMBT1.

Full Name

Scavenger Receptor Cysteine Rich Family Member With 5 Domains

Function

Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces (By similarity).

Biological Process

Biological Process defense responseManual Assertion Based On ExperimentIBA:GO_Central
Biological Process defense response to Gram-negative bacteriumIEA:Ensembl
Biological Process defense response to Gram-positive bacteriumIEA:Ensembl
Biological Process detection of bacterial lipoproteinISS:UniProtKB
Biological Process innate immune responseIEA:UniProtKB-KW
Biological Process negative regulation of interleukin-8 productionISS:UniProtKB

Cellular Location

Secreted
Cytoplasm