SSTR3

This gene encodes a member of the somatostatin receptor protein family. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This protein is functionally coupled to adenylyl cyclase. Alternate splicing results in multiple transcript variants.

Full Name

Somatostatin Receptor 3

Function

Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.

Biological Process

Biological Process cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Biological Process cellular response to estradiol stimulusIEA:Ensembl
Biological Process cellular response to glucocorticoid stimulusIEA:Ensembl
Biological Process cerebellum developmentIEA:Ensembl
Biological Process forebrain developmentIEA:Ensembl
Biological Process G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerManual Assertion Based On ExperimentTAS:ProtInc
Biological Process hormone-mediated apoptotic signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process response to starvationIEA:Ensembl
Biological Process spermatogenesisIEA:Ensembl

Cellular Location

Cell membrane
Internalized into endoplasmic vesicles upon somatostatin-stimulation.

Topology

Extracellular: 1-43
Helical: 44-69
Cytoplasmic: 70-79
Helical: 80-101
Extracellular: 102-116
Helical: 117-138
Cytoplasmic: 139-161
Helical: 162-181
Extracellular: 182-205
Helical: 206-231
Cytoplasmic: 232-257
Helical: 258-279
Extracellular: 280-293
Helical: 294-316
Cytoplasmic: 317-418

PTM

Phosphorylated. Phosphorylation increases upon somatostatin binding (By similarity).