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STAT6

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. [provided by RefSeq]
Full Name
STAT6
Function
Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.
Biological Process
Cellular response to hydrogen peroxideIEA:Ensembl
Cellular response to reactive nitrogen speciesIEA:Ensembl
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Defense responseManual Assertion Based On ExperimentIBA:GO_Central
Gene expressionIEA:Ensembl
Growth hormone receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentIBA:GO_Central
Interleukin-4-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Mammary gland epithelial cell proliferationIEA:Ensembl
Mammary gland morphogenesisIEA:Ensemblegative regulation of transcription by RNA polymerase IIIEA:Ensembl
Negative regulation of type 2 immune responseIEA:Ensembl
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Positive regulation of isotype switching to IgE isotypesIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell population proliferationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Response to peptide hormoneManual Assertion Based On ExperimentIBA:GO_Central
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
T-helper 1 cell lineage commitmentIEA:Ensembl
Cellular Location
Cytoplasm
Nucleus
Translocated into the nucleus in response to phosphorylation.
PTM
Tyrosine phosphorylated on Tyr-641 following stimulation by IL4/interleukin-4 (PubMed:27796300).
Tyrosine phosphorylated following stimulation by IL3/interleukin-3 (By similarity).
Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling (PubMed:17210636).
Mono-ADP-ribosylated by PARP14.

Anti-STAT6 antibodies

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Mouse Anti-STAT6 Monoclonal Antibody (1C6) (CBMAB-0208-LY)

Datasheet SDS
Target: STAT6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1C6
Application*: IP, E, WB

Rabbit Anti-STAT6 Recombinant Antibody (CBXS-6148) (CBMAB-S6311-CQ)

Datasheet SDS
Target: STAT6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-6148
Application*: WB, IP, IC, F

Mouse Anti-STAT6 Recombinant Antibody (CBXS-3452) (CBMAB-S6183-CQ)

Datasheet SDS
Target: STAT6
Host: Mouse
Specificity: Human
Clone: CBXS-3452
Application*: WB

Mouse Anti-STAT6 Recombinant Antibody (CBXS-3396) (CBMAB-S6130-CQ)

Datasheet SDS
Target: STAT6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-3396
Application*: F

Mouse Anti-STAT6 Recombinant Antibody (CBXS-3365) (CBMAB-S6102-CQ)

Datasheet SDS
Target: STAT6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBXS-3365
Application*: E, WB

Mouse Anti-STAT6 Recombinant Antibody (CBXS-3251) (CBMAB-S5992-CQ)

Datasheet SDS
Target: STAT6
Host: Mouse
Specificity: Human
Clone: CBXS-3251
Application*: E, IF, WB

Mouse Anti-STAT6 Recombinant Antibody (CBXS-2473) (CBMAB-S5230-CQ)

Datasheet SDS
Target: STAT6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey, Mouse, Rat
Clone: CBXS-2473
Application*: E, WB

Mouse Anti-STAT6 Recombinant Antibody (CBXS-2164) (CBMAB-S4927-CQ)

Datasheet SDS
Target: STAT6
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBXS-2164
Application*: WB, IP, IF, E

Mouse Anti-STAT6 Recombinant Antibody (CBXS-2122) (CBMAB-S4886-CQ)

Datasheet SDS
Target: STAT6
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBXS-2122
Application*: WB, IP, IF, P, E

Mouse Anti-STAT6 Recombinant Antibody (CBXS-2119) (CBMAB-S4884-CQ)

Datasheet SDS
Target: STAT6
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBXS-2119
Application*: WB, IP, IF, P

Rat Anti-STAT6 Recombinant Antibody (CBXS-1988) (CBMAB-S4757-CQ)

Datasheet SDS
Target: STAT6
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-1988
Application*: IC

Rat Anti-STAT6 Recombinant Antibody (CBXS-1987) (CBMAB-S4756-CQ)

Datasheet SDS
Target: STAT6
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-1987
Application*: WB

Rat Anti-STAT6 Recombinant Antibody (CBXS-1890) (CBMAB-S4684-CQ)

Datasheet SDS
Target: STAT6
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXS-1890
Application*: WB

Rabbit Anti-STAT6 Recombinant Antibody (CBXS-1669) (CBMAB-S4513-CQ)

Datasheet SDS
Target: STAT6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1669
Application*: WB, IC

Rabbit Anti-STAT6 Recombinant Antibody (CBXS-1451) (CBMAB-S4309-CQ)

Datasheet SDS
Target: STAT6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1451
Application*: WB, F, IF

Mouse Anti-STAT6 Recombinant Antibody (CBXS-1101) (CBMAB-S3987-CQ)

Datasheet SDS
Target: STAT6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-1101
Application*: E

Mouse Anti-STAT6 Recombinant Antibody (CBXS-0761) (CBMAB-S3689-CQ)

Datasheet SDS
Target: STAT6
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-0761
Application*: IH

Mouse Anti-STAT6 Recombinant Antibody (CBXS-5276) (CBMAB-S2490-CQ)

Datasheet SDS
Target: STAT6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog, Human
Clone: CBXS-5276
Application*: C, E, WB

Mouse Anti-STAT6 Recombinant Antibody (CBXS-5259) (CBMAB-S2474-CQ)

Datasheet SDS
Target: STAT6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBXS-5259
Application*: IC, IF, WB

Rabbit Anti-STAT6 Recombinant Antibody (CBXS-4271) (CBMAB-S1520-CQ)

Datasheet SDS
Target: STAT6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBXS-4271
Application*: CI, F, IC, IF, P, WB

Mouse Anti-STAT6 Recombinant Antibody (CBXS-5801) (CBMAB-S0658-CQ)

Datasheet SDS
Target: STAT6
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-5801
Application*: WB, P, IF

Mouse Anti-STAT6 Recombinant Antibody (CBXS-1117) (CBMAB-S0405-CQ)

Datasheet SDS
Target: STAT6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-1117
Application*: F, IF, IF

Human Anti-STAT6 Recombinant Antibody (CBXS-3556) (CBMAB-S0398-CQ)

Datasheet SDS
Target: STAT6
Host: Human
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBXS-3556
Application*: F

Mouse Anti-STAT6 Recombinant Antibody (CBXS-5728) (CBMAB-S0269-CQ)

Datasheet SDS
Target: STAT6
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-5728
Application*: WB, E

Mouse Anti-STAT6 Recombinant Antibody (CBXS-5668) (CBMAB-S0262-CQ)

Datasheet SDS
Target: STAT6
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-5668
Application*: WB, E

Mouse Anti-STAT6 Recombinant Antibody (CBXS-4629) (CBMAB-S0243-CQ)

Datasheet SDS
Target: STAT6
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-4629
Application*: WB, E

Mouse Anti-STAT6 Recombinant Antibody (CBXS-3765) (CBMAB-S0221-CQ)

Datasheet SDS
Target: STAT6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBXS-3765
Application*: WB, IP

Rabbit Anti-STAT6 Recombinant Antibody (YE361) (CBMAB-S0197-CQ)

Datasheet SDS
Target: STAT6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: YE361
Application*: F, IF

Mouse Anti-STAT6 Recombinant Antibody (CBXS-1734) (CBMAB-S0105-CQ)

Datasheet SDS
Target: STAT6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-1734
Application*: IS

Mouse Anti-STAT6 Recombinant Antibody (7D3) (CBMAB-AO993LY)

Datasheet SDS
Target: STAT6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Monkey
Clone: 7D3
Application*: WB, IF

Rabbit Anti-STAT6 Recombinant Antibody (D3H4) (CBMAB-CP2620-LY)

Datasheet SDS
Target: STAT6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey, Cattle, Dog, Pig
Clone: D3H4
Application*: WB, IP, CI

Mouse Anti-STAT6 Recombinant Antibody (6C10) (CBMAB-A8654-LY)

Datasheet SDS
Target: STAT6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 6C10
Application*: WB, E

Mouse Anti-STAT6 Recombinant Antibody (4G7) (CBMAB-A8653-LY)

Datasheet SDS
Target: STAT6
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4G7
Application*: WB, E

Mouse Anti-Stat6 Recombinant Antibody (2B2-B6-D7) (CBMAB-Z0470-LY)

Datasheet SDS
Target: STAT6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Monkey
Clone: 2B2-B6-D7
Application*: WB, IC

Rabbit Anti-STAT6 (Phosphorylated Y641) Recombinant Antibody (C11A12) (PTM-CBMAB-0538LY)

Datasheet SDS
Target: STAT6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: C11A12
Application*: WB

Mouse Anti-STAT6 (Phosphorylated Y641) Recombinant Antibody (6D782) (PTM-CBMAB-0458LY)

Datasheet SDS
Target: STAT6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6D782
Application*: E, WB

Mouse Anti-STAT6 (Phosphorylated Y641) Recombinant Antibody (16E12) (PTM-CBMAB-0302LY)

Datasheet SDS
Target: STAT6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 16E12
Application*: C, E, WB

Mouse Anti-STAT6 (Phosphorylated Y641) Recombinant Antibody (A15137E) (PTM-CBMAB-0105LY)

Datasheet SDS
Target: STAT6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A15137E
Application*: IS

STAT6 Matched Antibody Pair (1151) (APMAB-1151LY)

Datasheet SDS
Target: STAT6
Specificity: Human
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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