STK25

This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene.

Full Name

STK25

Function

Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration.

Biological Process

Biological Process axonogenesisIEA:Ensembl
Biological Process establishment of Golgi localizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process establishment or maintenance of cell polarityIEA:Ensembl
Biological Process Golgi localizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process Golgi reassemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process intrinsic apoptotic signaling pathway in response to hydrogen peroxideManual Assertion Based On ExperimentIGI:UniProtKB
Biological Process positive regulation of axonogenesisIEA:Ensembl
Biological Process positive regulation of stress-activated MAPK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein autophosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to hydrogen peroxideManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to oxidative stressManual Assertion Based On ExperimentTAS:ProtInc
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cytoplasm
Golgi apparatus
Localizes to the Golgi apparatus.