THBS1

The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008]

THBS1 Gene(Protein Coding) Thrombospondin 1

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity).
Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity).

Biological Process behavioral response to painSource:UniProtKB
Biological Process cell adhesionSource:BHF-UCL1 Publication
Biological Process cell migrationSource:BHF-UCL1 Publication
Biological Process cellular response to growth factor stimulusSource:Ensembl
Biological Process cellular response to heatSource:BHF-UCL1 Publication
Biological Process cellular response to tumor necrosis factorSource:Ensembl
Biological Process chronic inflammatory responseSource:BHF-UCL1 Publication
Biological Process engulfment of apoptotic cellSource:BHF-UCL1 Publication
Biological Process immune responseSource:BHF-UCL1 Publication
Biological Process inflammatory responseSource:CACAO1 Publication
Biological Process negative regulation of angiogenesisSource:UniProtKB1 Publication
Biological Process negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class IISource:BHF-UCL1 Publication
Biological Process negative regulation of apoptotic processSource:UniProtKB1 Publication
Biological Process negative regulation of blood vessel endothelial cell migrationSource:BHF-UCL1 Publication
Biological Process negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesisSource:BHF-UCL1 Publication
Biological Process negative regulation of cell migration involved in sprouting angiogenesisSource:BHF-UCL1 Publication
Biological Process negative regulation of cell population proliferationSource:BHF-UCL1 Publication
Biological Process negative regulation of cell-matrix adhesionSource:BHF-UCL1 Publication
Biological Process negative regulation of cGMP-mediated signalingSource:BHF-UCL1 Publication
Biological Process negative regulation of cysteine-type endopeptidase activity involved in apoptotic processSource:UniProtKB1 Publication
Biological Process negative regulation of dendritic cell antigen processing and presentationSource:BHF-UCL1 Publication
Biological Process negative regulation of endothelial cell chemotaxisSource:MGI1 Publication
Biological Process negative regulation of endothelial cell migrationSource:BHF-UCL1 Publication
Biological Process negative regulation of endothelial cell proliferationSource:BHF-UCL1 Publication
Biological Process negative regulation of extrinsic apoptotic signaling pathwaySource:BHF-UCL1 Publication
Biological Process negative regulation of fibrinolysisSource:BHF-UCL1 Publication
Biological Process negative regulation of fibroblast growth factor receptor signaling pathwaySource:BHF-UCL1 Publication
Biological Process negative regulation of focal adhesion assemblySource:BHF-UCL1 Publication
Biological Process negative regulation of interleukin-12 productionSource:BHF-UCL1 Publication
Biological Process negative regulation of long-chain fatty acid import across plasma membraneSource:BHF-UCL1 Publication
Biological Process negative regulation of nitric oxide mediated signal transductionSource:BHF-UCL1 Publication
Biological Process negative regulation of plasminogen activationSource:BHF-UCL1 Publication
Biological Process negative regulation of sprouting angiogenesisSource:BHF-UCL1 Publication
Biological Process peptide cross-linkingSource:BHF-UCL1 Publication
Biological Process positive regulation of angiogenesisSource:BHF-UCL2 Publications
Biological Process positive regulation of blood coagulationSource:BHF-UCL1 Publication
Biological Process positive regulation of blood vessel endothelial cell migrationSource:BHF-UCL1 Publication
Biological Process positive regulation of cell migrationSource:BHF-UCL1 Publication
Biological Process positive regulation of cell population proliferationSource:BHF-UCL1 Publication
Biological Process positive regulation of chemotaxisSource:BHF-UCL1 Publication
Biological Process positive regulation of endothelial cell apoptotic processSource:UniProtKB1 Publication
Biological Process positive regulation of endothelial cell migrationSource:BHF-UCL1 Publication
Biological Process positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsSource:BHF-UCL1 Publication
Biological Process positive regulation of fibroblast migrationSource:BHF-UCL1 Publication
Biological Process positive regulation of macrophage activationSource:BHF-UCL1 Publication
Biological Process positive regulation of macrophage chemotaxisSource:BHF-UCL
Biological Process positive regulation of MAP kinase activitySource:BHF-UCL1 Publication
Biological Process positive regulation of phosphorylationSource:BHF-UCL1 Publication
Biological Process positive regulation of protein kinase B signalingSource:UniProtKB1 Publication
Biological Process positive regulation of reactive oxygen species metabolic processSource:BHF-UCL1 Publication
Biological Process positive regulation of smooth muscle cell proliferationSource:BHF-UCL1 Publication
Biological Process positive regulation of transforming growth factor beta receptor signaling pathwaySource:BHF-UCL1 Publication
Biological Process positive regulation of transforming growth factor beta1 productionSource:BHF-UCL
Biological Process positive regulation of translationSource:BHF-UCL1 Publication
Biological Process positive regulation of tumor necrosis factor productionSource:UniProtKB1 Publication
Biological Process response to calcium ionSource:BHF-UCL2 Publications
Biological Process response to endoplasmic reticulum stressSource:UniProtKB
Biological Process response to glucoseSource:BHF-UCL1 Publication
Biological Process response to hypoxiaSource:BHF-UCL1 Publication
Biological Process response to magnesium ionSource:BHF-UCL1 Publication
Biological Process response to mechanical stimulusSource:Ensembl
Biological Process response to progesteroneSource:BHF-UCL1 Publication
Biological Process response to testosteroneSource:Ensembl
Biological Process response to unfolded proteinSource:UniProtKB-KW
Biological Process response to xenobiotic stimulusSource:UniProtKB1 Publication
Biological Process sprouting angiogenesisSource:BHF-UCL1 Publication