TNNI3K

TNNI3K is a protein that belongs to the MAP kinase kinase kinase (MAPKKK) family of protein kinases. TNNI3K contains ankyrin repeat, protein kinase and serine-rich domains and is thought to function in cardiac physiology.

Full Name

TNNI3 Interacting Kinase

Function

May play a role in cardiac physiology.

Biological Process

Biological Process bundle of His cell to Purkinje myocyte communication Source:BHF-UCL1 Publication
Biological Process protein phosphorylation Source:UniProtKB1 Publication
Biological Process regulation of cardiac conduction Source:BHF-UCL1 Publication
Biological Process regulation of cardiac muscle contraction Source:BHF-UCL1 Publication
Biological Process regulation of heart rate Source:BHF-UCL1 Publication
Biological Process regulation of postsynapse organization Source:GO_Central1 Publication

Cellular Location

Nucleus
Cytoplasm
Expressed at lower levels in the cytoplasm.

Involvement in disease

Cardiac conduction disease with or without dilated cardiomyopathy (CCDD):
A cardiac disorder characterized by atrial tachyarrhythmia and conduction system disease. Some patients have dilated cardiomyopathy.

PTM

Autophosphorylated.