TNNI3K
TNNI3K is a protein that belongs to the MAP kinase kinase kinase (MAPKKK) family of protein kinases. TNNI3K contains ankyrin repeat, protein kinase and serine-rich domains and is thought to function in cardiac physiology.
Full Name
TNNI3 Interacting Kinase
Function
May play a role in cardiac physiology.
Biological Process
Biological Process bundle of His cell to Purkinje myocyte communication Source:BHF-UCL1 Publication
Biological Process protein phosphorylation Source:UniProtKB1 Publication
Biological Process regulation of cardiac conduction Source:BHF-UCL1 Publication
Biological Process regulation of cardiac muscle contraction Source:BHF-UCL1 Publication
Biological Process regulation of heart rate Source:BHF-UCL1 Publication
Biological Process regulation of postsynapse organization Source:GO_Central1 Publication
Biological Process protein phosphorylation Source:UniProtKB1 Publication
Biological Process regulation of cardiac conduction Source:BHF-UCL1 Publication
Biological Process regulation of cardiac muscle contraction Source:BHF-UCL1 Publication
Biological Process regulation of heart rate Source:BHF-UCL1 Publication
Biological Process regulation of postsynapse organization Source:GO_Central1 Publication
Cellular Location
Nucleus
Cytoplasm
Expressed at lower levels in the cytoplasm.
Cytoplasm
Expressed at lower levels in the cytoplasm.
Involvement in disease
Cardiac conduction disease with or without dilated cardiomyopathy (CCDD):
A cardiac disorder characterized by atrial tachyarrhythmia and conduction system disease. Some patients have dilated cardiomyopathy.
A cardiac disorder characterized by atrial tachyarrhythmia and conduction system disease. Some patients have dilated cardiomyopathy.
PTM
Autophosphorylated.
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Anti-TNNI3K antibodies
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Target: TNNI3K
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-4090
Application*: WB, IP, IF, E
Target: Tnni3k
Sensitivity: 0.0053 ng/mL
Detection Range: 0.01-2 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: Tnni3k
Sensitivity: 0.0048 ng/mL
Detection Range: 0.01-2 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Target: TNNI3K
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 300-end
Tag: GST Tag
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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