TRIM32

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes. [provided by RefSeq]

tripartite motif-containing 32

Has an E3 ubiquitin ligase activity (PubMed:19349376, PubMed:31123703).
Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation (PubMed:19349376).
May ubiquitinate BBS2 (PubMed:22500027).
Ubiquitinates PIAS4/PIASY and promotes its degradation in keratinocytes treated with UVB and TNF-alpha (By similarity).
Also acts as a regulator of autophagy by mediating formation of unanchored 'Lys-63'-linked polyubiquitin chains that activate ULK1: interaction with AMBRA1 is required for ULK1 activation (PubMed:31123703).By Similarity3 Publications
(Microbial infection) May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo (PubMed:7778269).
Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo (PubMed:7778269).

Biological Process actin ubiquitination Source:Ensembl
Biological Process axon development Source:Ensembl
Biological Process fat cell differentiation Source:BHF-UCL
Biological Process free ubiquitin chain polymerization Source:UniProtKB1 Publication
Biological Process innate immune response Source:UniProtKB1 Publication
Biological Process muscle cell cellular homeostasis Source:Ensembl
Biological Process negative regulation of fibroblast proliferation Source:BHF-UCL
Biological Process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source:BHF-UCL1 Publication
Biological Process negative regulation of viral transcription Source:UniProtKB1 Publication
Biological Process positive regulation of autophagy Source:UniProtKB1 Publication
Biological Process positive regulation of cell cycle Source:BHF-UCL1 Publication
Biological Process positive regulation of cell growth Source:BHF-UCL1 Publication
Biological Process positive regulation of cell migration Source:BHF-UCL1 Publication
Biological Process positive regulation of cell motility Source:BHF-UCL
Biological Process positive regulation of chemokine (C-C motif) ligand 20 production Source:Ensembl
Biological Process positive regulation of DNA-binding transcription factor activity Source:UniProtKB1 Publication
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process positive regulation of interleukin-17-mediated signaling pathway Source:Ensembl
Biological Process positive regulation of neurogenesis Source:BHF-UCL
Biological Process positive regulation of neuron differentiation Source:BHF-UCL
Biological Process positive regulation of NF-kappaB transcription factor activity Source:UniProtKB1 Publication
Biological Process positive regulation of protein catabolic process Source:BHF-UCL
Biological Process positive regulation of proteolysis Source:BHF-UCL1 Publication
Biological Process positive regulation of striated muscle cell differentiation Source:Ensembl
Biological Process positive regulation of tumor necrosis factor-mediated signaling pathway Source:Ensembl
Biological Process protein K48-linked ubiquitination Source:GO_Central1 Publication
Biological Process protein polyubiquitination Source:BHF-UCL1 Publication
Biological Process protein ubiquitination Source:BHF-UCL1 Publication
Biological Process response to tumor necrosis factor Source:BHF-UCL
Biological Process response to UV Source:BHF-UCL
Biological Process suppression of viral release by host Source:UniProtKB1 Publication
Biological Process tissue homeostasis Source:Ensembl
Biological Process ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication

Cytoplasm
Localized in cytoplasmic bodies, often located around the nucleus.

Muscular dystrophy, limb-girdle, autosomal recessive 8 (LGMDR8):
An autosomal recessive degenerative myopathy characterized by pelvic girdle, shoulder girdle and quadriceps muscle weakness. Clinical phenotype and severity are highly variable. Disease progression is slow and most patients remain ambulatory into the sixth decade of life.
Bardet-Biedl syndrome 11 (BBS11):
A syndrome characterized by usually severe pigmentary retinopathy, early-onset obesity, polydactyly, hypogenitalism, renal malformation and intellectual disability. Secondary features include diabetes mellitus, hypertension and congenital heart disease. Bardet-Biedl syndrome inheritance is autosomal recessive, but three mutated alleles (two at one locus, and a third at a second locus) may be required for clinical manifestation of some forms of the disease.

Ubiquitinated.