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WRAP53

This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene.

Anti-WRAP53 antibodies

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Cat Product Name Target Host Antibody Isotype Cross Reactivity Clone Application*
CBMAB-W0045-WJ Mouse Anti-WRAP53 Recombinant Antibody (1F12) WRAP53 Mouse IgG2a, κ Human 1F12 WB, IP, IF, E
CBMAB-W0174-WJ Mouse Anti-WRAP53 Recombinant Antibody (CBWJW-017) WRAP53 Mouse IgG2a Human CBWJW-017 WB, E
PEP-152676CQ Human WRAP53 Peptide (GRSLGLYAW) WRAP53
PEP-063971CQ Human WRAP53 Peptide (HPSPHASPM) WRAP53
PEP-152675CQ Human WRAP53 Peptide (SSAQPDTSY) WRAP53
PEP-152674CQ Human WRAP53 Peptide (IYFDLDPTGQF) WRAP53
PEP-152673CQ Human WRAP53 Peptide (AEMVPVLRM) WRAP53
PEP-152672CQ Human WRAP53 Peptide (TEFGSPSEL) WRAP53
PEP-152671CQ Human WRAP53 Peptide (STQPENFLK) WRAP53
PEP-152670CQ Human WRAP53 Peptide (SPMNKNADSEL) WRAP53
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)