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ZFYVE9

This gene encodes a double zinc finger motif-containing protein that participates in the transforming growth factor-beta (TGFB) signalling pathway. The encoded protein interacts directly with SMAD2 and SMAD3, and recruits SMAD2 to the TGFB receptor. There are multiple pseudogenes for this gene on chromosomes 2, 15, and X. Alternative splicing results in multiple transcript variants.
Full Name
Zinc Finger FYVE-Type Containing 9
Function
Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.
Biological Process
Biological Process endocytosis Source:UniProtKB1 Publication
Biological Process endosomal transport Source:GO_Central1 Publication
Biological Process transforming growth factor beta receptor signaling pathway Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
Early endosome membrane
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Anti-ZFYVE9 antibodies

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Rabbit Anti-ZFYVE9 Recombinant Antibody (CBXS-1523) (CBMAB-S4374-CQ)

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Target: ZFYVE9
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat, Human
Clone: CBXS-1523
Application*: WB, IP, P, F
Datasheet SDS

Rabbit Anti-ZFYVE9 Recombinant Antibody (CBXS-5414) (CBMAB-S2626-CQ)

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Target: ZFYVE9
Host: Rabbit
Specificity: Human
Clone: CBXS-5414
Application*: WB, IP
Datasheet SDS

Rabbit Anti-ZFYVE9 Recombinant Antibody (D5X4F) (CBMAB-CP2353-LY)

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Target: ZFYVE9
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D5X4F
Application*: WB, IP
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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