ZFYVE9

This gene encodes a double zinc finger motif-containing protein that participates in the transforming growth factor-beta (TGFB) signalling pathway. The encoded protein interacts directly with SMAD2 and SMAD3, and recruits SMAD2 to the TGFB receptor. There are multiple pseudogenes for this gene on chromosomes 2, 15, and X. Alternative splicing results in multiple transcript variants.

Full Name

Zinc Finger FYVE-Type Containing 9

Function

Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.

Biological Process

Biological Process endocytosis Source:UniProtKB1 Publication
Biological Process endosomal transport Source:GO_Central1 Publication
Biological Process transforming growth factor beta receptor signaling pathway Source:UniProtKB1 Publication

Cellular Location

Cytoplasm
Early endosome membrane

Anti-ZFYVE9 antibodies

Rabbit Anti-ZFYVE9 Recombinant Antibody (CBXS-5414) (CBMAB-S2626-CQ)

Datasheet

SDS

Target: ZFYVE9

Host: Rabbit

Specificity: Human

Clone: CBXS-5414

Application*: WB, IP

Rabbit Anti-ZFYVE9 Recombinant Antibody (CBXS-1523) (CBMAB-S4374-CQ)

Datasheet

SDS

Target: ZFYVE9

Host: Rabbit

Antibody Isotype: IgG

Specificity: Rat, Human

Clone: CBXS-1523

Application*: WB, IP, P, F

Rabbit Anti-ZFYVE9 Recombinant Antibody (D5X4F) (CBMAB-CP2353-LY)

Datasheet

SDS

Target: ZFYVE9

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: D5X4F

Application*: WB, IP

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)