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Mouse Anti-TBL1 Recombinant Antibody (4H2-D5-E9) (CBMAB-Z0459-LY)

The product is antibody recognizes TBL1. The antibody 4H2-D5-E9 immunoassay techniques such as: WB, ICC.
See all TBL1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4H2-D5-E9
Antibody Isotype
IgG2b
Application
WB, ICC

Basic Information

Immunogen
Purified recombinant human TBL1 protein fragments expressed in E.coli.
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Purified mouse monoclonal antibody in PBS (pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TBL1
Entrez Gene ID
6907
UniProt ID
O60907
Alternative Names
EBI; TBL1; SMAP55.
Function
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units (PubMed:14980219).
Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (PubMed:21240272).
Biological Process
Biological Process histone deacetylationIBA:GO_Central1 Publication
Biological Process negative regulation of transcription by RNA polymerase IIIDA:UniProtKB1 Publication
Biological Process positive regulation of canonical Wnt signaling pathwayIMP:UniProtKB1 Publication
Biological Process positive regulation of DNA-templated transcriptionIDA:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase IIIDA:UniProtKB1 Publication
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic processISS:UniProtKB
Biological Process protein stabilizationISS:UniProtKB
Biological Process proteolysisIMP:UniProtKB1 Publication
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Biological Process sensory perception of soundIMP:UniProtKB1 Publication
Cellular Location
Nucleus
Colocalized with MECP2 to the heterochromatin foci.
Involvement in disease
Hypothyroidism, congenital, non-goitrous, 8 (CHNG8):
A form of central hypothyroidism, a disorder characterized by sub-optimal thyroid hormone secretion, due to insufficient stimulation by the thyroid stimulating hormone of an otherwise normal thyroid gland. It may be caused by congenital or acquired disorders of the pituitary gland or hypothalamus. CHNG8 is a congenital, X-linked, relatively mild form which may be accompanied by hearing loss in some patients.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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